This peptide corresponds to 16 amino acids near the carboxy terminus of mouse Smac.
PEP-0100 can be used as a blocking peptide with polyclonal antibody PA5-19975.
DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).
蛋白别名: Diablo homolog, mitochondrial; Diablo IAP-binding mitochondrial protein; DIABLO-S; direct IAP binding protein with low PI; Direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Smac; SMAC3
基因别名: 0610041G12Rik; 1700006L01Rik; AU040403; Diablo; Smac
UniProt ID: (Mouse) Q9JIQ3
Entrez Gene ID: (Mouse) 66593