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Invitrogen
Rat IFN-alpha 2 Recombinant Protein
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产品信息
131001
产品规格
种属
Rat
Expression System
E. coli
分子量
19 kDa
分类
Recombinant
类型
Protein
纯度
>95%
内毒素浓度
<1 EU/µg
活性
EC50 ~ 1 U/mL; determined by use of the cytopathic effect inhibition assay described in [Rubinstein, S. et al. (1981). J. Virol. 37, 755-758]; [Familletti, P.C. et al. (1981). Methods in Enzymology, Vol. 78, 387-394]As there is no international Rat IFN-alpha standard, units are determined with respect to the international reference standard for mouse interferon alpha/beta (mouse IFN-alpha/beta) provided by the National Institutes of Health.
偶联物
形式
Lyophilized
纯化类型
purified
保存液
citric acid, pH 5, with NaCl, 0.125M trehalose
内含物
no preservative
保存条件
4°C
运输条件
Wet ice
产品详细信息
Each blood donation used for interferon production tested negative for: HBsAg, HIV I-II, HCV and VDRL.
After receipt, this product should be kept at 4°C while lyophilized and at -70°C after reconstitution in sterile distilled water for retention of full activity. After reconstitution store at -70°C in aliquots. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Further dilute only in buffers containing protein such as 0.1% bovine serum albumin (BSA).
靶标信息
IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IFN-a; IFN-alpha 1b; IFN-alpha-1/13; IFNA 2; Interferon; interferon alpha 1b; interferon alpha family, gene 2; interferon alpha-D; Interferon-alpha II; leIF D; RP11-354P17.2
Entrez Gene ID: (Rat) 298213
