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Human Ret quantitates human Ret in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Ret.
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development, and can undergo oncogenic activation by cytogenetic rearrangement. RET transduce signals for cell growth and differentiation. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for the RET gene. Additional transcript variants have been described for RET but their biological validity has not been confirmed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET, RET-ELE1, RET51
基因ID : (Human) 5979
基因符号 : RET
蛋白别名 : Cadherin family member 12, Cadherin family member 12 (CDHF12), Cadherin related family member 16 (CDHR16), EC 2.7.10.1, ELKS, Hydroxyaryl protein kinase, kinase Ret, Multiple endocrine neoplasia and medullary thyroid carcinoma 1, Oncogene RET, OTTHUMP00000216967, RET ELE1, cadherin-related family member 16, CUX1/RET fusion, hydroxyaryl-protein kinase, Proto-oncogene c-Ret, Proto-oncogene tyrosine-protein kinase receptor Ret, rearranged during transfection, receptor tyrosine kinase, ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease), RET receptor tyrosine kinase, RET transforming sequence
UniProt ID (Human) P07949