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产品规格
检测灵敏度
Lot-specific
测定范围
Lot-specific
手工操作时间
1 hr 45 min
总时间
24 hr 30 min
均相（无需洗涤）
No
检测仪器
Absorbance Microplate Reader
产品规格
10 x 96 Tests
产品成分
This Human TRAIL (CD253) ELISA Kit includes Capture Antibody, Detection Antibody, Protein Standard, and HRP-conjugate. The HRP-conjugate is packaged separately.
储存
Refer to product documentation for component specific storage temperature.
蛋白名称
TRAIL (CD253)
蛋白家族
Growth Factors & Receptors
均相（无需洗涤）
Human
检测试剂盒格式
ELISA Development Kit
检测抗体结合物
Biotin
标签或染料
HRP
关于本试剂盒
900-K141K consists of: 900-K141 (capture antibody, detection antibody, and protein standard), and AVIDIN-60UL (avidin HRP-conjugate).
Human TRAIL (CD253) ABTS ELISA Development Kit contains the key components required for the quantitative measurement of natural and/or recombinant human TRAIL (CD253) in a sandwich ELISA format. Human TRAIL (CD253) ABTS ELISA Development Kit contains enough material to assay the target cytokine in at least 1,000 ELISA plate wells.
The ABTS ELISA Buffer Kit (Product # 900-K00), sold separately, is recommended to be used in conjunction with this ABTS ELISA Development Kit for optimal performance. This buffer kit contains all the necessary components to assay ten 96-well ELISA plates (included) and contains detailed handling instructions.
靶标信息
TRAIL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TRAIL preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of TRAIL protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Receptors for TRAIL include two death domain containing receptors, death receptor 4 (DR4) and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. TRAIL is a type II membrane protein and expressed in a variety of human tissues. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
基因别名 : Apo-2L, APO2L, CD253, TL2, TNFSF10, TNLG6A, TRAIL
基因ID : (Human) 8743
基因符号 : TNFSF10
蛋白别名 : Apo-2 ligand, Apo-2L, CD253, CD253 antigen, TN, TNF superfamily member 10, TRAIL protein, chemokine tumor necrosis factor ligand superfamily member 10, Protein TRAIL, TNF-related apoptosis inducing ligand TRAIL, TNF-related apoptosis-inducing ligand, tumor necrosis factor (ligand) family, member 10, tumor necrosis factor (ligand) superfamily member 10, tumor necrosis factor (ligand) superfamily, tumor necrosis factor apoptosis-inducing ligand splice variant delta, tumor necrosis factor ligand 6A, Tumor necrosis factor ligand superfamily member 10
UniProt ID (Human) P50591
