The connecting segment between both epidermal growth factor-like domains in blood coagulation factor IX contributes to stimulation by factor VIIIa and its isolated A2 domain.
Authors:Celie Patrick H N; Van Stempvoort Gunny; Fribourg Caroline; Schurgers Leon J; Lenting Peter J; Mertens Koen;
Journal:J Biol Chem
PubMed ID:11925427
The light chain of activated factor IX comprises multiple interactions between both epidermal growth factor-like domains that contribute to enzymatic activity and binding of factor IXa to its cofactor factor VIIIa. To investigate the association between factor IXa-specific properties and surface-exposed structure elements, chimeras were constructed in which the interconnection ... More
Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival.
Authors: Wang Y Lynn; Frauwirth Kenneth A; Rangwala Shamina M; Lazar Mitchell A; Thompson Craig B;
Journal:J Biol Chem
PubMed ID:12082115
'Thiazolidinediones (TZDs) are widely used for treatment of type 2 diabetes mellitus. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is the molecular target of TZDs and is believed to mediate the apoptotic effects of this class of drugs in a variety of cell types, including B and T lymphocytes. The finding ... More
Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation.
Authors: Gao Gui; Westling Jennifer; Thompson Vivian P; Howell Troy D; Gottschall Paul E; Sandy John D;
Journal:J Biol Chem
PubMed ID:11796708
'Proteolysis of the hyalectans (aggrecan, versican, brevican) in vivo appears to result from the activity of ADAMTS4 (aggrecanase-1, herein referred to as an hyalectanase). To examine the mode of activation of ADAMTS4, a human chondrosarcoma cell line, JJ012, has been stably transfected with the full-length c-DNA for human ADAMTS4. The ... More