Enhancing transcription-replication conflict targets ecDNA-positive cancers.
Authors:Tang J,Weiser NE,Wang G,Chowdhry S,Curtis EJ,Zhao Y,Wong IT,Marinov GK,Li R,Hanoian P,Tse E,Mojica SG,Hansen R,Plum J,Steffy A,Milutinovic S,Meyer ST,Luebeck J,Wang Y,Zhang S,Altemose N,Curtis C,Greenleaf WJ,Bafna V,Benkovic SJ,Pinkerton AB,Kasibhatla S,Hassig CA,Mischel PS,Chang HY
Journal:Nature
PubMed ID:39506153
Extrachromosomal DNA (ecDNA) presents a major challenge for cancer patients. ecDNA renders tumours treatment resistant by facilitating massive oncogene transcription and rapid genome evolution, contributing to poor patient survival(1-7). At present, there are no ecDNA-specific treatments. Here we show that enhancing transcription-replication conflict enables targeted elimination of ecDNA-containing cancers. Stepwise ... More