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View additional product information for Human Plateable Hepatocytes, Metabolism Qualified - FAQs (HMCPMS)
10 product FAQs found
Our hepatocytes are prequalified and sold according to application, such as induction, short-term metabolism, and transporter uptake. If you require hepatocytes with particular P450 values or donor specifications, contact our Hepatic Biology Tech Support Team (hepaticproducts@thermofisher.com.com) or (866) 952-3559 to help with specific lot recommendations.
Thermo Fisher Scientific has a dedicated team to answer questions regarding hepatocyte cell culture. You can send a question by email (hepaticproducts@thermofisher.com) or contact us by phone: US toll-free: (866) 952-3559
Thermofisher Scientific works with a variety of human tissue sources, including Tissue and Organ Procurement Organizations, qualified Research Tissue Organizations and prominent academic and medical centers through collaborations that follow rigorous regulations, certifications and/or accreditations (“Source Facilities”). Tissues obtained through source facilities are consistent with the applicable legal and ethical practices of the United States.
Source Facilities are required by federal law to maintain accurate records and donor confidentiality as well as adhere to certain applicable laws governing tissue used for research globally. These include, but are not limited to:
- 45 CFR Part 46, subparts A, B, C, D where applicable (US federal guidance on the use of human subjects in research)
- Health Insurance Portability and Accountability Act (HIPAA) (addressing issues of confidentiality of personal information)
- National Organ Transplant Act (42 CFR Part 482)
- The Uniform Anatomical Gift Act (UAGA) of 1968, revised 1984
The human liver cells are derived from tissue obtained from accredited institutions. Consent is obtained by these institutions from the donor or the donor’s legal next of kin, for the use of the tissue and its derivatives for research purpose.
Hepatocytes need to be plated on collagen I-coated culture vessels.
Find additional tips, troubleshooting help, and resources within our Cell Culture Support Center.
Our hepatocytes are prequalified and sold according to application, such as induction, short-term metabolism, and transporter uptake. If you require cells with particular P450 values or donor specifications, please contact our Hepatic Biology Tech Support Team at hepaticproducts@invitrogen.com to help with specific lot recommendations.
A service level agreement (SLA) is required ONLY if you are working in a laboratory in the European Union. An SLA is designed to comply with the UK's Human Tissue Authority (HTA) regulations and outlines the scope of use for human biologicals.
Yes, we comply with country-specific legal and ethical standards for procurement of human liver tissue, including the global ICH Guidelines, and the US's HIPAA, Uniform Anatomical Gift Act, National Organ Transplant Act, and Hospital Internal Review Board (IRB) approval processes.
We source liver tissue from a network of hospitals in North America that perform surgical resections on living donors, as well as from deceased donors whose organs were rejected for transplant.
No. The overlay will interfere with transfection. For transfection assays, we recommend that you perform the transfection first, and then proceed to overlay the cells.