Calciferol, 97%, Thermo Scientific Chemicals

Catalog Number	Quantity
J62163.06 also known as J62163-06	5g

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Catalog number J62163.06

also known as J62163-06

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Chemical Identifiers

CAS50-14-6

IUPAC Name(1S,3E)-3-{2-[(1R,3aS,4E,7aR)-1-[(2R,3E,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexan-1-ol

Molecular FormulaC28H44O

InChI KeyMECHNRXZTMCUDQ-VLOQVYPSSA-N

SMILESCC(C)[C@@H](C)\C=C\[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1/C[C@@H](O)CCC1=C

Specifications

Optical Rotation+103 to + 106º

Assay (HPLC)97.0 to 103.0 %

Identification (FTIR)Conforms to structure

FormCrystalline powder

Assay (unspecified)Reducing substances: ≤ 20 ppm

Calciferol has a strong inhibitory effect against bladder tumor promotion by sodium saccharin and induces cell differentiation in leukemia cells. Calciferol has also been shown to be an inhibitor of DNA polymerase. Calciferol with calcium is used to treat or prevent bone loss (osteoporosis). Calciferol is also used with other medications to treat low levels of calcium or phosphate caused by certain disorders (such as hypoparathyroidism, pseudohypoparathyroidism, familial hypophosphatemia). It is often used in kidney disease to keep calcium levels normal and allow normal bone growth.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in ethanol (80 mg/ml at 25°C), water (<1mg/mL at 25°C), methanol, DMF (∼20 mg/ml), and DMSO (20 mg/ml at 25°C).

Notes
Store at 4°C. Incompatible with heat and oxidizing agents.

RUO – Research Use Only

Gui-Dong. Zhu.; William H. Okamura. Synthesis of Vitamin D (Calciferol).Chem. Rev. 1995, 95 (6),1877-1952 .

Maryka H. Bhattacharyya.; H.F. DeLuca. Subcellular location of rat liver calciferol-25-hydroxylase. Arch. Biochem. Biophys. 1974, 160 (1),58-62 .