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Invitrogen
BCL-2 Monoclonal Antibody (SPM117)
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产品信息
MA1-34340
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
SPM117
抗原
synthetic peptide GAAPAPGIFS SQPG, corresponding to amino acids 41-54 of Human Bcl2 alpha.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
100 µg
保存条件
4°C
运输条件
Wet ice
产品详细信息
MA1-34340 detects Bcl2 from human samples.
MA1-34340 has been successfully used in flow cytometry, immunofluorescence, immunohistochemistry (paraffin tissue), Western blot, immunoprecipitation applications.
The MA1-34340 immunogen is: Synthetic peptide: GAAPAPGIFS SQPG, corresponding to amino acids 41-54 of Human Bcl2 alpha.
靶标信息
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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