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Invitrogen
hCG beta Monoclonal Antibody (5H4-E2)
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Product Details
MA1-35020
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5H4-E2
Immunogen
hCG beta, cojugated to various carrier proteins
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
100 µg/mL
Amount
100 µg
Purification
purified
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
5H4-E2 reacts with hCG beta chain, which is specific for hCG. The alpha chain is identical among hCG, TSH, FSH and LH. While hCG is secreted in large quantities by normal trophoblasts, it is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. Besides trophoblastic tumors e.g. choriocarcinoma, large cell carcinoma, adenocarcinoma and squamous cell carcinoma of the lung are also positive in 90%, 60% and 20% of cases respectively. In hCG producing tumors, including also certain testicular and embryonic carcinomas, the beta chain is produced in higher quantities than the alpha or dimeric chains. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.
Target Information
hCG beta is the beta chain of hCG (Human chorionic gonadotropin), a 40 kDa glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. hCG is made up of alpha and beta subunits that are non-covalently associated. The alpha subunit is similar to those found on the pituitary hormones FSH, LH ans TSH. However, the beta subunit is different in FSH, LH and TSH and are involved in conferring biological specificity. Maintenance of the fetus in the first trimester of pregnancy requires the production of hCG, which binds to the corpus luteum of the ovary which is stimulated to produce progesterone which in turn maintains the secretory endometrium. hCG is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and Beta subunits. The alpha subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). Diseases associated with Hcg dysfunction include gestational trophoblastic tumor and hydatidiform mole, recurrent 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CG-beta; Choriogonadotropin subunit beta; Choriogonadotropin subunit beta 3; chorionic gonadotrophin chain beta; chorionic gonadotropin beta 3 subunit; chorionic gonadotropin beta chain; chorionic gonadotropin beta subunit 3; Chorionic gonadotropin chain beta; chorionic gonadotropin human; chorionic gonadotropin, beta polypeptide; FSH-alpha; human chorionic gonadotropin; LSH-alpha; luteinizing hormone beta subunit; TSH-alpha; unnamed protein product
Gene Aliases: CGB; CGB3; CGB5; CGB7; CGB8; hCGB; LHB
UniProt ID: (Human) P0DN86
Entrez Gene ID: (Human) 1082
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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