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Invitrogen

Phospho-HDAC4/HDAC5/HDAC7 (Ser246, Ser259, Ser155) Monoclonal Antibody (B.544.8)

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Phospho-HDAC4/HDAC5/HDAC7 (Ser246, Ser259, Ser155) Monoclonal Antibody (B.544.8)

Product Details

MA5-14776

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

ChIP assay (ChIP)

1-3 µL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

B.544.8

Immunogen

Synthetic phosphopeptide corresponding to pSer155 of human HDAC7 protein
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980952

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: antigen NY-CO-9; class II histone deacetylase; hdac-7; HDAC4; HDAC5; HDAC7_pr1; HDAC7_pr2; HDAC7_pr3; histone deacetylase 4; histone deacetylase 7A; histone deacetylase A; histone deacetylase mHDA1; protein deacetylase HDAC7; putative Type II integral membrane protein; unnamed protein product

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Gene Aliases: 4932408F19Rik; 5830434K02Rik; AHO3; BDMR; HA6116; HD4; HD5; HD7; HD7A; HDAC-4; HDAC-A; Hdac4; HDAC7A; HDACA; mFLJ00062; mHDA1; mKIAA0600; NEDCHF; NEDCHID; NY-CO-9

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UniProt ID: (Human) P56524, (Human) Q9UQL6, (Human) Q8WUI4, (Mouse) Q6NZM9, (Mouse) Q8C2B3

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Entrez Gene ID: (Human) 9759, (Human) 10014, (Human) 51564, (Mouse) 208727, (Mouse) 15184, (Mouse) 56233

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding histone deacetylase activity protein binding zinc ion binding SUMO transferase activity potassium ion binding protein deacetylase activity histone binding identical protein binding histone deacetylase binding binding, bridging RNA polymerase II sequence-specific DNA binding transcription factor binding DNA-binding transcription factor binding histone deacetylase activity, hydrolytic mechanism transcription corepressor binding chromatin binding protein kinase C binding transcription corepressor activity protein kinase binding 14-3-3 protein binding DNA binding promoter-specific chromatin binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter chromatin remodeling inflammatory response nervous system development positive regulation of cell proliferation negative regulation of myotube differentiation response to denervation involved in regulation of muscle adaptation cardiac muscle hypertrophy in response to stress protein sumoylation B cell differentiation positive regulation of protein sumoylation regulation of gene expression, epigenetic B cell activation negative regulation of gene expression, epigenetic negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter type I interferon signaling pathway negative regulation of protein refolding response to interleukin-1 osteoblast development chromatin organization heart development response to xenobiotic stimulus negative regulation of gene expression regulation of myotube differentiation multicellular organismal response to stress response to cocaine negative regulation of osteoblast differentiation negative regulation of striated muscle tissue development negative regulation of transcription, DNA-templated regulation of skeletal muscle fiber development regulation of striated muscle cell differentiation renal tubule morphogenesis cellular response to fluid shear stress negative regulation of cell migration involved in sprouting angiogenesis positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation response to activity neuron differentiation cellular response to insulin stimulus cellular response to lipopolysaccharide protein deacetylation negative regulation of interleukin-2 production regulation of mRNA processing positive regulation of cell migration involved in sprouting angiogenesis negative regulation of NIK/NF-kappaB signaling skeletal system development negative regulation of cell proliferation positive regulation of lamellipodium assembly regulation of cardiac muscle contraction by calcium ion signaling positive regulation of smooth muscle cell migration positive regulation of neuron apoptotic process positive regulation of smooth muscle cell proliferation positive regulation of male mating behavior negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of reactive oxygen species biosynthetic process vasculogenesis cell-cell junction assembly membraneless organelle assembly
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