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Invitrogen
Phospho-HDAC4/HDAC5/HDAC7 (Ser246, Ser259, Ser155) Monoclonal Antibody (B.544.8)
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Phospho-HDAC4/HDAC5/HDAC7 (Ser246, Ser259, Ser155) Antibody (MA5-14776) in ChIP
Chromatin immunoprecipitation analysis of HDAC4 (pSer246)/HDAC5 (pSer259)/HDAC7 (pSer155) was performed using cross-linked chromatin from 1x10^6 HCT116 colon carcinoma cells treated with serum for 0, 15, and 30 minutes. Immunoprecipitation was performed using a multiplex microplate Matrix ChIP assay (see reference for Matrix ChIP protocol: http://www.ncbi.nlm.nih.gov/pubmed/22098709) with 1.0 µL/100 µL well... View More
产品信息
MA5-14776
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
B.544.8
抗原
Synthetic phosphopeptide corresponding to pSer155 of human HDAC7 protein
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
<0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Antigen NY-CO-9; HD4; HD5; HD7; HD7a; hdac-7; HDAC4; HDAC5; Histone deacetylase 4; Histone deacetylase 5; Histone deacetylase 7; Histone deacetylase 7A; histone deacetylase A; histone deacetylase mHDA1; Protein deacetylase HDAC7; putative Type II integral membrane protein; unnamed protein product
基因别名: 4932408F19Rik; 5830434K02Rik; AHO3; AI047285; AI426555; BDMR; HA6116; HD4; HD5; HD7; HD7A; HDAC-4; HDAC-A; HDAC4; HDAC5; HDAC7; HDAC7A; HDACA; KIAA0288; KIAA0600; mFLJ00062; mHDA1; mKIAA0600; NEDCHF; NEDCHID; NY-CO-9
UniProt ID: (Human) P56524, (Human) Q9UQL6, (Human) Q8WUI4, (Mouse) Q6NZM9, (Mouse) Q8C2B3
Entrez Gene ID: (Human) 9759, (Human) 10014, (Human) 51564, (Mouse) 208727, (Mouse) 15184, (Mouse) 56233
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
histone deacetylase activity
protein binding
zinc ion binding
hydrolase activity
SUMO transferase activity
potassium ion binding
protein deacetylase activity
histone binding
identical protein binding
histone deacetylase binding
metal ion binding
binding, bridging
RNA polymerase II sequence-specific DNA binding transcription factor binding
DNA-binding transcription factor binding
histone deacetylase activity, hydrolytic mechanism
transcription corepressor binding
chromatin binding
protein kinase C binding
transcription corepressor activity
protein kinase binding
14-3-3 protein binding
RNA polymerase III transcription factor binding
core promoter binding
DNA binding
transcription factor binding
histone deacetylase activity (H3-K14 specific)
NAD-dependent histone deacetylase activity (H3-K14 specific)
histone deacetylase activity (H3-K9 specific)
activating transcription factor binding
histone deacetylase activity (H4-K16 specific)
sequence-specific DNA binding
transcription regulatory region DNA binding
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
repressing transcription factor binding
NAD-dependent histone deacetylase activity (H3-K18 specific)
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
chromatin remodeling
protein deacetylation
inflammatory response
nervous system development
positive regulation of cell proliferation
negative regulation of macromolecule biosynthetic process
negative regulation of myotube differentiation
negative regulation of transcription by competitive promoter binding
response to denervation involved in regulation of muscle adaptation
cardiac muscle hypertrophy in response to stress
protein sumoylation
B cell differentiation
positive regulation of protein sumoylation
regulation of gene expression, epigenetic
B cell activation
negative regulation of gene expression, epigenetic
negative regulation of glycolytic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
type I interferon signaling pathway
response to interleukin-1
response to xenobiotic stimulus
regulation of myotube differentiation
response to activity
neuron differentiation
cellular response to insulin stimulus
response to cocaine
negative regulation of transcription, DNA-templated
cellular response to lipopolysaccharide
negative regulation of cell migration involved in sprouting angiogenesis
vasculogenesis
cell-cell junction assembly
negative regulation of interleukin-2 production
negative regulation of osteoblast differentiation
regulation of mRNA processing
positive regulation of cell migration involved in sprouting angiogenesis
membraneless organelle assembly
negative regulation of NIK/NF-kappaB signaling
skeletal system development
osteoblast development
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of cell proliferation
positive regulation of lamellipodium assembly
regulation of cardiac muscle contraction by calcium ion signaling
positive regulation of smooth muscle cell migration
chromatin modification
histone deacetylation
peptidyl-lysine deacetylation
response to drug
regulation of protein binding
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of neuron apoptotic process
positive regulation of smooth muscle cell proliferation
regulation of skeletal muscle fiber development
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of striated muscle cell differentiation
histone H3 deacetylation
histone H4 deacetylation
positive regulation of reactive oxygen species biosynthetic process
transcription from RNA polymerase II promoter
heart development
negative regulation of gene expression
multicellular organismal response to stress
negative regulation of striated muscle tissue development
renal tubule morphogenesis
cellular response to fluid shear stress
positive regulation of neural precursor cell proliferation
positive regulation of stem cell proliferation
negative regulation of neuron death
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