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Invitrogen
JNK1 Monoclonal Antibody (1E5)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-17117
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1E5
抗原
Purified recombinant fragment of human MAPK8 expressed in E. Coli.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-17117 targets MAPK8 in FACS, indirect ELISA, and WB applications and shows reactivity with Human and Mouse samples.
The MA5-17117 immunogen is purified recombinant fragment of human MAPK8 expressed in E. Coli.
MA5-17117 detects MAPK8 which has a predicted molecular weight of approximately 48.3kDa.
靶标信息
MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum. It is also a crucial mediator of insulin resistance and obesity. It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-Jun N-terminal kinase 1; FLJ12099; FLJ33785; JNK-46; JNK1 beta1 protein kinase; MAP kinase 8; MAPK 8; MGC50974; mitogen activated protein kinase 8; Mitogen-activated protein kinase 8; OTTHUMP00000019552; p493F12; p54bSAPK; protein kinase JNK1; protein kinase mitogen-activated 8; SAPK1c; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1
基因别名: AI849689; JNK; JNK1; MAPK8; PRKM8; SAPK1; SAPK1C
UniProt ID: (Mouse) Q91Y86
Entrez Gene ID: (Mouse) 26419
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
JUN kinase activity
MAP kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
enzyme binding
histone deacetylase regulator activity
histone deacetylase binding
non-receptor serine/threonine protein kinase
ossification
regulation of transcription, DNA-templated
protein phosphorylation
inflammatory response
response to osmotic stress
signal transduction
JNK cascade
JUN phosphorylation
response to heat
response to UV
regulation of gene expression
positive regulation of gene expression
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of cell migration
regulation of histone deacetylation
positive regulation of microtubule polymerization
neuron projection development
positive regulation of cyclase activity
negative regulation of protein binding
regulation of protein localization
response to hydrogen peroxide
regulation of circadian rhythm
negative regulation of apoptotic process
positive regulation of DNA replication
response to cadmium ion
determination of dorsal identity
rhythmic process
positive regulation of protein metabolic process
cellular response to hydrogen peroxide
cellular response to lipopolysaccharide
cellular response to nitric oxide
positive regulation of deacetylase activity
type B pancreatic cell apoptotic process
neuronal stem cell population maintenance
programmed necrotic cell death
positive regulation of determination of dorsal identity
positive regulation of apoptotic signaling pathway
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