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Invitrogen
SOX9 Monoclonal Antibody (1B11)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-17177
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B11
Immunogen
Purified recombinant fragment of human SOX9 expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-17177 targets SOX9 in indirect ELISA, ICC, IF and WB applications and shows reactivity with Human samples.
The MA5-17177 immunogen is purified recombinant fragment of human SOX9 expressed in E. Coli.
MA5-17177 detects SOX9 which has a predicted molecular weight of approximately 56kDa.
Target Information
SOX9 has a role in sex determination and differentiation of Sertoli cells. It is involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Translocation of this gene can cause campomelic dysplasia. SOX9 is involved in the formation of testes from the indifferent fetal gonads. It is a major molecular component of the neuron-glia switch in developing spinal cord. During normal development, SOX9 allows the prostate epithelium to outgrow into the mesenchyme and then provides basal cell support for development and maintenance of the luminal epithelium. These functions of SOX9 are subverted in prostate cancer to support tumor growth and invasion. SOX9 may direct the formation of neural crest precursors and the development of a range of neural crest derivative. It has a transcriptional regulation in melanin production in cells. Northern blot analysis shows its expression on adult testis, adult heart, and fetal brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: SOX 9; SOX9; SRY (sex determining region Y)-box9; SRY (sex-determining region Y)-box 9 protein; SRY-box 9; SRY-Box 9 ; SRY-related HMG-box, gene 9; unnamed protein product
Gene Aliases: CMD1; CMPD1; ENH13; SRA1; SRXX2; SRXY10; TESCO
UniProt ID: (Human) P48436
Entrez Gene ID: (Human) 6662
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
protein kinase A catalytic subunit binding
bHLH transcription factor binding
sequence-specific DNA binding
pre-mRNA intronic binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
cartilage condensation
ossification
branching involved in ureteric bud morphogenesis
cell fate specification
epithelial to mesenchymal transition
tissue homeostasis
hair follicle development
morphogenesis of an epithelium
positive regulation of mesenchymal cell proliferation
chondrocyte differentiation
negative regulation of immune system process
heart valve development
heart valve morphogenesis
aortic valve morphogenesis
endocardial cushion morphogenesis
chondrocyte differentiation involved in endochondral bone morphogenesis
chondrocyte hypertrophy
growth plate cartilage chondrocyte growth
nucleosome assembly
chromatin remodeling
signal transduction
epidermal growth factor receptor signaling pathway
spermatogenesis
central nervous system development
heart development
positive regulation of cell proliferation
male gonad development
gene expression
regulation of cell cycle process
positive regulation of gene expression
positive regulation of epithelial cell migration
neural crest cell fate specification
male germ-line sex determination
negative regulation of ossification
prostate gland development
positive regulation of epithelial cell differentiation
mammary gland development
notochord development
otic vesicle formation
negative regulation of chondrocyte differentiation
positive regulation of chondrocyte differentiation
somatic stem cell population maintenance
regulation of cell proliferation
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of myoblast differentiation
negative regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of fatty acid oxidation
negative regulation of photoreceptor cell differentiation
oligodendrocyte differentiation
positive regulation of epithelial cell proliferation
negative regulation of epithelial cell proliferation
cartilage development
Sertoli cell differentiation
Sertoli cell development
retina development in camera-type eye
limb bud formation
retinal rod cell differentiation
epithelial cell proliferation involved in prostatic bud elongation
intestinal epithelial structure maintenance
regulation of cell proliferation involved in tissue homeostasis
positive regulation of cartilage development
morphogenesis of a branching epithelium
protein-containing complex assembly
negative regulation of biomineral tissue development
ERK1 and ERK2 cascade
response to fatty acid
cellular response to mechanical stimulus
cellular response to retinoic acid
cellular response to interleukin-1
cellular response to epidermal growth factor stimulus
cellular response to heparin
cellular response to transforming growth factor beta stimulus
otic vesicle development
cellular response to BMP stimulus
renal vesicle induction
metanephric tubule development
ureter urothelium development
metanephric nephron tubule formation
negative regulation of canonical Wnt signaling pathway
cochlea morphogenesis
positive regulation of kidney development
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of chondrocyte proliferation
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of beta-catenin-TCF complex assembly
positive regulation of male gonad development
positive regulation of mesenchymal stem cell differentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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