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Invitrogen
RAB21 Monoclonal Antibody (OTI6E12)
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FIGURE: 1 / 7
RAB21 Antibody (MA5-26200) in ICC/IF
Immunofluorescence analysis of RAB21 was performed using 70% confluent log phase MCF7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with RAB21 Monoclonal Antibody (OTI6E12) (Product # MA5-26200) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ Plus 488 (Product # A32766)... View More
Product Details
MA5-26200
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI6E12
Immunogen
Full length human recombinant protein of RAB21 produced in HEK293T cell
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
RAB21 is a member of a subfamily of small GTP-binding protein genes of the Ras superfamily that plays an important role in intracellular vesicular targeting. In non-polarized Caco-2 cells, RAB21 showed a general endoplasmic reticulum (ER)-like localization, while in polarized cells, RAB21 localized to apical vesicles. RAB21 has been shown to associate with integrin subunits and to be important for receptor entry into cells via RAB5/RAB21 endosomes. The GTPase-activating protein p120RasGAP regulates cell motility by controlling the return of the endocytosed integrins to the plasma membrane by competing with RAB21 for binding to overlapping sites on the Alpha-tail of endocytosed integrin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTP-binding protein RAB21; KIAA0118; Rab-12; RAB21; Ras-related protein Rab-21
Gene Aliases: 9630024B22; KIAA0118; RAB21
UniProt ID: (Human) Q9UL25, (Dog) P55745, (Rat) Q6AXT5, (Mouse) P35282
Entrez Gene ID: (Human) 23011, (Dog) 100683312, (Rat) 299799, (Mouse) 216344
intracellular protein transport
anterograde axonal transport
protein transport
regulation of exocytosis
regulation of axon extension
Rab protein signal transduction
positive regulation of receptor-mediated endocytosis
positive regulation of dendrite morphogenesis
protein stabilization
positive regulation of early endosome to late endosome transport
metabolic process
regulation of endocytosis
transport
small GTPase mediated signal transduction
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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