Search
Invitrogen
DYNLL1 Recombinant Rabbit Monoclonal Antibody (SD08-04)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 6
DYNLL1 Antibody (MA5-32384) in ICC/IF
Immunocytochemical analysis of DYNLL1 in HepG2 cells using a DYNLL1 Monoclonal antibody (Product # MA5-32384) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-32384
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SD08-04
Immunogen
Synthetic peptide within Human DYNLL1 aa 1-50.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1, 200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. DYNLL1 is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: 8 kDa dynein light chain; 8kD LC; 8kDa LC; cytoplasmic dynein light polypeptide; DLC1DNCLC1; DLC8MGC126137; DNCL1; DNCL1MGC126138; dynein LC8; dynein, cytoplasmic, light chain 1; dynein, cytoplasmic, light peptide; dynein, cytoplasmic, light polypeptide 1; H LC8; LC8-type 1; MGC126137; MGC126138; mPIN; PINLC8a; protein inhibitor of neuronal nitric oxide synthase; protein inhibitor of nitric oxide synthase; unnamed protein product
Gene Aliases: 8kDLC; DLC1; DLC8; DNCL1; DNCLC1; hdlc1; LC8; LC8a; PIN
UniProt ID: (Human) P63167, (Mouse) P63168, (Rat) P63170
Entrez Gene ID: (Human) 8655, (Mouse) 56455, (Rat) 58945
enzyme inhibitor activity
protein binding
enzyme binding
protein domain specific binding
nitric-oxide synthase regulator activity
nitric-oxide synthase inhibitor activity
identical protein binding
macromolecular complex binding
dynein intermediate chain binding
scaffold protein binding
deoxyribonuclease inhibitor activity
microtubule-based process
spermatid development
intraciliary retrograde transport
positive regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of phosphorylation
motile cilium assembly
negative regulation of nitric oxide biosynthetic process
regulation of mitochondrial membrane potential
DNA strand resection involved in replication fork processing
negative regulation of DNA strand resection involved in replication fork processing
mitocytosis
positive regulation of nonmotile primary cilium assembly
substantia nigra development
positive regulation of intracellular transport
positive regulation of mitotic cell cycle spindle assembly checkpoint
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support