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Invitrogen
IP3 Receptor 1 Recombinant Rabbit Monoclonal Antibody (4Z1B6)
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FIGURE: 1 / 5
IP3 Receptor 1 Antibody (MA5-35516) in IHC (P)
Immunohistochemistry analysis of IP3 Receptor 1 in paraffin-embedded mouse brain. Samples were incubated with IP3 Receptor 1 Monoclonal antibody (Product # MA5-35516) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-35516
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4Z1B6
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 2200-2300 of human IP3R (Q14643)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.33 mg/mL
Amount
33 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HTAQIEIVRL DRTMEQIVFP VPSICEFLTK ESKLRIYYTT ERDEQGSKIN DFFLRSEDLF NEMNWQKKLR AQPVLYWCAR NMSFWSSISF NLAVLMNLLV A
Target Information
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases:
inositol 1,4,5 trisphosphate receptor; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate-binding protein P400; inositol-1,4,5-triphosphate receptor; inositol-1,4,5-triphosphate receptor (alt., clone pI16); InsP>3
Gene Aliases: D6Pas2; Gm10429; I145TR; InsP3R; InsP3R1; Ip3r; IP3R 1; IP3R1; Itpr-1; opt; P400; Pcp-1; Pcp1; wblo
UniProt ID: (Mouse) P11881, (Rat) P29994
Entrez Gene ID: (Mouse) 16438, (Rat) 25262
ion channel activity
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
calcium channel activity
calcium ion binding
protein binding
ATP binding
calcium-release channel activity
calcium channel inhibitor activity
protein phosphatase binding
protein domain specific binding
phosphatidylinositol binding
identical protein binding
protein homodimerization activity
ion channel binding
macromolecular complex binding
inositol 1,4,5 trisphosphate binding
inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
cell morphogenesis
response to hypoxia
ion transport
calcium ion transport
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
single fertilization
post-embryonic development
positive regulation of neuron projection development
calcium-mediated signaling
endoplasmic reticulum calcium ion homeostasis
calcium ion transmembrane import into mitochondrion
epithelial fluid transport
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of calcium-mediated signaling
voluntary musculoskeletal movement
release of sequestered calcium ion into cytosol
protein homotetramerization
regulation of cytosolic calcium ion concentration
positive regulation of calcium ion transport
transmembrane transport
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
calcium ion transmembrane transport
cellular response to cAMP
liver regeneration
regulation of postsynaptic cytosolic calcium ion concentration
release of sequestered calcium ion into cytosol by endoplasmic reticulum
positive regulation of hepatocyte proliferation
dendrite development
regulation of calcium-mediated signaling
cellular response to hypoxia
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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