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Invitrogen

HES5 Recombinant Rabbit Monoclonal Antibody (4S4U7)

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HES5 Recombinant Rabbit Monoclonal Antibody (4S4U7)

Product Details

MA5-38214

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:6,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4S4U7

Immunogen

Recombinant protein (or fragment)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.9 mg/mL

Amount

90 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898131

Product Specific Information

Positive Samples: Mouse brain, Mouse spleen, Rat brain, Rat spleen

Immunogen sequence: SPKEKNRLRK PVVEKMRRDR INSSIEQLKL LLEQEFARHQ PNSKLEKADI LEMAVSYLKH SKAFVAAAGP KSLHQDYSEG YSWCLQEAVQ FLTLHAASDT QMKLLYHFQR PPAAPAAPAK EPKAPGAAPP P

Target Information

Hairy and Enhancer-of-split homologues 5 (HES5) is a helix-loop-helix transcriptional factor that negatively regulates cell differentiation during embryogenesis. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. HES5 is reported to be a down stream effector of the Notch Signaling Pathway and is expressed in advanced ovarian serous adenocarcinomas as well as in cervical squamous carcinoma. Reports also suggest that HES5 is abundantly expressed in osteoarthritis along with Notch1 and Jagged1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: class B basic helix-loop-helix protein 38; hairy and enhancer of split 5; Notch pathway transcription factor; RP3-395M20.5; unnamed protein product

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Gene Aliases: bHLHb38

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UniProt ID: (Human) Q5TA89, (Mouse) P70120, (Rat) Q03062

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Entrez Gene ID: (Human) 388585, (Mouse) 15208, (Rat) 79225

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding protein dimerization activity sequence-specific double-stranded DNA binding chromatin binding double-stranded DNA binding protein binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter chondrocyte differentiation regulation of transcription, DNA-templated cell adhesion Notch signaling pathway smoothened signaling pathway brain development positive regulation of cell proliferation anterior/posterior pattern specification oligodendrocyte development telencephalon development glial cell fate commitment forebrain radial glial cell differentiation neural tube development central nervous system myelination neuron differentiation positive regulation of BMP signaling pathway regulation of myelination camera-type eye development regulation of cell differentiation negative regulation of auditory receptor cell differentiation negative regulation of neuron differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JAK-STAT cascade cell maturation animal organ development positive regulation of smooth muscle cell proliferation astrocyte differentiation negative regulation of astrocyte differentiation negative regulation of oligodendrocyte differentiation system development regulation of epithelial cell proliferation regulation of neurogenesis cartilage development inner ear receptor stereocilium organization protein-containing complex assembly comma-shaped body morphogenesis S-shaped body morphogenesis specification of loop of Henle identity metanephric nephron tubule morphogenesis establishment of epithelial cell polarity neuronal stem cell population maintenance negative regulation of stem cell differentiation negative regulation of pro-B cell differentiation negative regulation of forebrain neuron differentiation negative regulation of inner ear receptor cell differentiation negative regulation of cell differentiation
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