Hamburger Menu Button
Thermo Fisher Scientific Logo
Sign in
Don't have an account ? Create Account
  • Products
    • PCR Equipment and Supplies
    • Chromatography Columns and Cartridges
    • Lab Centrifuges
    • Molecular Biology Reagents and Kits
    • Lab Plasticware and Supplies
    • See all product categories
  • Applications
    • Chromatography
    • Cell Culture
    • Real-Time PCR
    • Mass Spectrometry
    • Lab Plasticware and Supplies
    • Electron Microscopy
    • Protein Biology
    • PCR
    • RNAi
    • Environmental
    • See all applications and techniques
  • Services
    • Custom Services
    • Enterprise-Level Lab Informatics
    • Financial and Leasing Services
    • Instrument Services
    • OEM and Commercial Supply
    • Training Services
    • 360° CDMO and CRO Solutions
    • CDMO Services
    • CRO Services
    • Unity Lab Services
    • See all services
  • Help and Support
    • Learning Centers
    • Contact Us
    • Change Location
    • See all help and support topics
  • Popular
    • TaqMan Real-Time PCR Assays
      TaqMan Real-Time PCR Assays
    • Antibodies
      Antibodies
    • Oligos, Primers & Probes
      Oligos, Primers & Probes
    • GeneArt Gene Synthesis
      GeneArt Gene Synthesis
    • Cell Culture Plastics
      Cell Culture Plastics
  • Who We Serve
    • Antibody Therapy Solution
    • Cell and Gene Therapy Solution
    • Academic
    • Industrial and Applied Sciences
  • New Products
  • Contact Us
  • Quick Order
  • Order Status and Tracking
  • Documents and Certificates
Thermo Fisher Scientific Logo

Search

Search All
Search button
          • Contact Us
          • Quick Order
          • Sign in
            Sign in
            Don't have an account ? Create Account
            • Account
            • Check Order Status
            • Membership
            • AR Statement & Invoice Inquiry
            • Custom Products & Projects
          • Primary Antibodies ›
          • PKC alpha/beta/gamma Antibodies

          Invitrogen

          PKC alpha/beta/gamma Recombinant Rabbit Monoclonal Antibody (24GB885)

          View all (2) PKC alpha/beta/gamma antibodies

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support
          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support
          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support

          Cite PKC alpha/beta/gamma Recombinant Rabbit Monoclonal Antibody (24GB885)

          {{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:

          {{$ctrl.translations[$ctrl.isSkuNotesCollapsed ? 'antibody.pdp.skuNotes.viewMore' : 'antibody.pdp.skuNotes.viewLess']}}
          • Antibody Testing Data (3)
          PKC alpha/beta/gamma Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          PKC alpha/beta/gamma Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 3

          {{ $ctrl.currentElement.advancedVerification.fullName }}
          {{ $ctrl.currentElement.advancedVerification.text }}

          PKC alpha/beta/gamma Antibody (MA5-57173) in ICC/IF

          Immunocytochemical staining of PKC alpha/beta/gamma in C2C12 cells using PKC alpha/beta/gamma Recombinant Monoclonal Antibody (Product # MA5-57173) at a 1:1,1000 dilution. Nuclei were stained blue with DAPI; PKC alpha + beta + gamma was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          View Product

          {{$ctrl.videoDesc}}

          {{$ctrl.videoLongDesc}}

          PKC alpha/beta/gamma Antibody in Immunocytochemistry (ICC/IF)
          PKC alpha/beta/gamma Antibody in Western Blot (WB)
          PKC alpha/beta/gamma Antibody in Flow Cytometry (Flow)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          PKC alpha/beta/gamma Recombinant Rabbit Monoclonal Antibody (24GB885)

          Product Details

          MA5-57173

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000-1:5,000
          -

          Immunocytochemistry (ICC/IF)

          1:100-1:1,000
          -

          Flow Cytometry (Flow)

          1:2,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Expression System

          HEK293F

          Class

          Recombinant Monoclonal

          Type

          Antibody

          Clone

          24GB885

          Immunogen

          A synthesized peptide derived from human PKC (aa 300-500)
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          2 mg/mL

          Amount

          200 µg

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Dry ice (international)

          RRID

          AB_3680198

          Target Information

          Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

          Have you cited this product in a publication?
          Let us know so we can reference it here.
          Cite this product

          Bioinformatics

          Protein Aliases: AAG6; aging-associated gene 6; PKC gamma; PKC-A; PKC-alpha; PKC-B; PKC-beta; PKC-gamma; protein kinase; protein kinase C alpha-polypeptide; protein kinase C beta I; protein kinase C beta II; protein kinase C beta-1; protein kinase C beta-II; protein kinase C type I (gamma type); protein kinase C type II; protein kinase C type III; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide; protein kinase c-alpha; unnamed protein product

          View more View less

          Gene Aliases: AAG6; PKC; PKC-alpha; PKC-B; PKC-Beta; PKC-gamma; PKCA; PKCalpha; PKCB; PKCbeta; PKCC; PKCG; PKCgamma; PKCI; PKCI(2); PKCI(3); PKCI+/-; Prkc; PRKCB1; PRKCB2; Prkcc; RATPKCI; SCA14

          View more View less

          UniProt ID: (Human) P17252, (Human) P05771, (Human) P05129, (Mouse) P20444, (Rat) P05696, (Rat) P68403, (Mouse) P68404, (Rat) P63319, (Mouse) P63318

          View more View less

          Entrez Gene ID: (Human) 5578, (Human) 5579, (Human) 5582, (Mouse) 18750, (Rat) 24680, (Rat) 25023, (Mouse) 18751, (Rat) 24681, (Mouse) 18752

          View more View less

          Function(s)
          protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-dependent protein kinase C activity receptor binding integrin binding protein binding ATP binding zinc ion binding enzyme binding diacylglycerol binding histone kinase activity (H3-T6 specific) protein serine kinase activity chromatin binding transcription coactivator activity protein kinase C binding calcium channel regulator activity histone binding androgen receptor binding protein serine/threonine/tyrosine kinase activity lipid binding
          Process(es)
          response to reactive oxygen species negative regulation of protein phosphorylation positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation regulation of the force of heart contraction chondrocyte differentiation desmosome assembly chromatin remodeling protein phosphorylation negative regulation of protein kinase activity cellular calcium ion homeostasis regulation of muscle contraction learning or memory negative regulation of cell proliferation positive regulation of signal transduction positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy negative regulation of glucose transport negative regulation of translation central nervous system neuron axonogenesis signal transduction involved in regulation of gene expression positive regulation of cell migration neutrophil chemotaxis positive regulation of lipopolysaccharide-mediated signaling pathway response to estradiol negative regulation of glial cell apoptotic process intracellular signal transduction peptidyl-serine autophosphorylation proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of MAPK cascade protein kinase B signaling positive regulation of blood vessel endothelial cell migration positive regulation of cellular component biogenesis response to ethanol positive regulation of macrophage differentiation positive regulation of angiogenesis positive regulation of bone resorption positive regulation of cell adhesion positive regulation of exocytosis positive regulation of mitotic cell cycle negative regulation of glucose import negative regulation of insulin receptor signaling pathway protein autophosphorylation positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response regulation of peptidyl-tyrosine phosphorylation induction of positive chemotaxis positive regulation of developmental process positive regulation of multicellular organismal process positive regulation of protein kinase B signaling positive regulation of synapse assembly renal sodium ion absorption positive regulation of ERK1 and ERK2 cascade protein kinase C signaling response to interleukin-1 cellular response to carbohydrate stimulus regulation of platelet aggregation intrinsic apoptotic signaling pathway positive regulation of angiotensin-activated signaling pathway negative regulation of cytokine production involved in inflammatory response response to phorbol 13-acetate 12-myristate regulation of synaptic vesicle exocytosis positive regulation of dense core granule biogenesis phospholipase C-activating G-protein coupled receptor signaling pathway chemical synaptic transmission chemosensory behavior response to toxic substance regulation of cell communication regulation of signaling negative regulation of protein ubiquitination regulation of response to food positive regulation of mismatch repair negative regulation of protein catabolic process regulation of circadian rhythm response to morphine negative regulation of neuron apoptotic process response to pain regulation of phagocytosis long-term synaptic potentiation innervation negative regulation of proteasomal protein catabolic process response to angiotensin response to psychosocial stress regulation of transcription from RNA polymerase II promoter mitotic nuclear envelope disassembly signal transduction phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway regulation of glucose transport positive regulation of vascular endothelial growth factor receptor signaling pathway B cell activation lipoprotein transport positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription, DNA-templated B cell receptor signaling pathway regulation of transport negative regulation of dopamine receptor signaling pathway positive regulation of ferroptosis response to mechanical stimulus positive regulation of insulin secretion response to peptide hormone regulation of mRNA stability response to corticosterone apoptotic signaling pathway positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway response to hypoxia calcium ion transport response to xenobiotic stimulus response to glucose regulation of signal transduction regulation of dopamine secretion dibenzo-p-dioxin metabolic process response to vitamin D regulation of growth positive regulation of odontogenesis of dentin-containing tooth regulation of secretion by cell synaptic signaling via neuropeptide regulation of exocytosis establishment of protein localization
          It has to be done as per old AB suggested Products section.

          Disclaimer

          Close

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          guarantee_icon

          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

          Learn more
          help_icon

          We're here to help

          Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

          Contact tech support
          Ordering Plus Icon Minus Icon
          • Order Status
          • Order Help
          • Quick Order
          • Supply Center
          • eProcurement
          Support Plus Icon Minus Icon
          • Help and Support
          • Contact Us - 400 820 8982
          • Instrument Quotation
          • Technical Support Centers
          • Documents and Certificates
          • Channel Partner Authorization
          • Report a Site Issue
          Resources Plus Icon Minus Icon
          • Learning Centers
          • Promotions
          • Events and Webinars
          • Social Media
          About Thermo Fisher Plus Icon Minus Icon
          • About Us About Us
          • Careers Careers
          • Investors Investors
          • News News
          • Social Responsibility Social Responsibility
          • Trademarks
          • Policies and Notices
          Our Portfolio Plus Icon Minus Icon
          • Thermo Scientific
          • Applied Biosystems
          • Invitrogen
          • Gibco
          • Ion Torrent
          • Unity Lab Services
          • Patheon
          • PPD
          • Terms & Conditions
          • Privacy Notice
          • Price & Freight Policy
          © 2006-2026 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
          China flag icon
          China
          本网站销售的所有产品均不得用于人类或动物之临床诊断或治疗,仅可用于工业或者科研等非医疗目的。
          经营证照公示 | ICP备案号:沪ICP备11003924号 | 沪公网安备 31011502006935号

          Your items have has been added!


          Host server : magellan-search-blue-7fb9f846c9-xq5gc:80/100.66.76.64:80.
          git-commit: 8207b5afa5c305bd40e0a4f0b9b53fd46f2a8829
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.59.1-2026.09.91-1.0