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Invitrogen
Pan Succinyl Lysine Recombinant Rabbit Monoclonal Antibody (4A3S5)
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FIGURE: 1 / 3
Pan Succinyl Lysine Antibody (MA568793) in WB
Western blot analysis of Pan Succinyl Lysine in HeLa cells. Samples were probed with Pan Succinyl Lysine recombinant monoclonal antibody (Product # MA568792) at 1:1,000 dilution incubated overnight at 4°C. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10,000 dilution. Lysates/proteins: 30 µg per lane. Blocking buffer: 3 % nonfat dry milk in TBST.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA568793
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4A3S5
Immunogen
Synthetic peptide.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.65 mg/mL
Amount
33 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3., with 50% glycerol, 0.05% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Pan-succinyl-lysine is a post-translational modification where a succinyl group is added to the lysine residue of a protein, influencing protein function and localization. This modification generally occurs in the mitochondria, where it plays a pivotal role in the regulation of metabolic enzymes. The succinyl group is transferred to lysine residues by specific enzymes, leading to changes in protein structure and activity. Succinylation is essential for processes like the tricarboxylic acid (TCA) cycle, fatty acid metabolism, and amino acid degradation. Dysregulation of lysine succinylation is associated with various diseases, including cancer and metabolic disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADP-ribosyltransferase diphtheria toxin-like 1; ADPRT 1; ARTD1; Carboxypeptidase A1; Casein kinase I isoform alpha; Casein kinase I isoform alpha-like; CASP-1; Caspase-1; CK1; CKI-alpha; CKI-alpha-like; DNA ADP-ribosyltransferase PARP1; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; ICE; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; interleukin 1 beta-converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; Microtubule-associated protein tau; NAD(+) ADP-ribosyltransferase 1; Neurofibrillary tangle protein; p45; Paired helical filament-tau; PARP-1; PHF-tau; Poly [ADP-ribose] polymerase 1; Poly[ADP-ribose] synthase 1; Protein poly-ADP-ribosyltransferase PARP1; Tubulin beta-2 chain; Tubulin beta-2C chain; Tubulin beta-4B chain
Gene Aliases: ADPRT; CASP1; CPA; CPA1; CSNK1A1; CSNK1A1L; H3C1; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3FA; H3FB; H3FC HIST1H3C; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; HIST1H3A; HIST1H3B; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; ICE; IL1BC; IL1BCE; MAPT; MAPTL; MTBT1; PARP1; PPOL; TAU; TUBB2C; TUBB4B
UniProt ID: (Mouse) P29452, (Rat) P97633
Entrez Gene ID: (Mouse) 12362, (Rat) 113927
endopeptidase activity
cysteine-type endopeptidase activity
protein binding
peptidase activity
cysteine-type peptidase activity
hydrolase activity
scaffold protein binding
magnesium ion binding
glycoprotein binding
protein kinase activity
protein serine/threonine kinase activity
ATP binding
peptide binding
phosphoprotein binding
non-receptor serine/threonine protein kinase
protease
response to hypoxia
microglial cell activation
proteolysis
apoptotic process
myoblast fusion
memory
response to bacterium
regulation of autophagy
response to organic cyclic compound
protein processing
response to lipopolysaccharide
interleukin-1 beta production
response to ATP
response to drug
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of cytokine secretion
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
mitochondrial depolarization
membrane hyperpolarization
pyroptosis
cellular response to organic substance
programmed necrotic cell death
toxin transport
cell morphogenesis
protein phosphorylation
phagocytosis
mitotic nuclear division
regulation of cell shape
Wnt signaling pathway
peptidyl-serine phosphorylation
cell division
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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