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FIGURE: 1 / 3
Pan-succinyl-lysine is a post-translational modification where a succinyl group is added to the lysine residue of a protein, influencing protein function and localization. This modification generally occurs in the mitochondria, where it plays a pivotal role in the regulation of metabolic enzymes. The succinyl group is transferred to lysine residues by specific enzymes, leading to changes in protein structure and activity. Succinylation is essential for processes like the tricarboxylic acid (TCA) cycle, fatty acid metabolism, and amino acid degradation. Dysregulation of lysine succinylation is associated with various diseases, including cancer and metabolic disorders.
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Protein Aliases: ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase NAD(+); ADPRT 1; ARTD1; Carboxypeptidase A1; carboxypeptidase A1 (pancreatic); casein kinase I alpha S-like; Casein kinase I isoform alpha; Casein kinase I isoform alpha-like; CASP-1; caspase 1, apoptosis-related cysteine peptidase; Caspase-1; CK1; CKI-alpha; CKI-alpha-like; class IVb beta tubulin; clock regulator kinase; CSNK1A1; cysteine protease; DNA ADP-ribosyltransferase PARP1; down-regulated in lung cancer; epididymis secretory sperm binding protein; epididymis secretory sperm binding protein Li 77p; G protein beta1/gamma2 subunit-interacting factor 1; H3 histone family, member A; HIST1H3A; histone 1, H3a; histone cluster 1 H3 family member a; histone cluster 1, H3a; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; ICE; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; IL1B-convertase; interleukin 1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; microtubule protein; Microtubule-associated protein tau; NAD(+) ADP-ribosyltransferase 1; Neurofibrillary tangle protein; p45; Paired helical filament-tau; pancreatic carboxypeptidase A; PARP-1; PHF-tau; poly (ADP-ribose) polymerase family, member 1; Poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; Poly[ADP-ribose] synthase 1; protein phosphatase 1, regulatory subunit 103; Protein poly-ADP-ribosyltransferase PARP1; Tau-derived paired helical filament hexapeptide; Tubulin beta-2 chain; Tubulin beta-2C chain; Tubulin beta-4B chain; tubulin, beta 2C; tubulin, beta, 2; unnamed protein product
Gene Aliases: ADPRT; ADPRT 1; ADPRT1; ARTD1; Beta2; CASP1; CK1; CK1a; CKIa; CPA; CPA1; CSNK1A1; CSNK1A1L; DDPAC; FTD1; FTDP-17; H3/A; H3C1; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3FA; H3FB; H3FC HIST1H3C; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; HEL-S-77p; HIST1H3A; HIST1H3B; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HLCDGP1; ICE; IL1BC; IL1BCE; LCAEOD; MAPT; MAPTL; MSTD; MTBT1; MTBT2; P45; pADPRT-1; PARP; PARP-1; PARP1; PARS; Poly-PARP; PPND; PPOL; PPP1R103; PRO2975; TAU; tau-40; Tau-PHF6; TUBB2; TUBB2C; TUBB4B
UniProt ID: (Human) P29466, (Human) P15085, (Human) P48729, (Human) Q8N752, (Mouse) P29452, (Rat) P97633, (Human) P68431, (Human) P10636, (Human) P09874, (Human) P68371
Entrez Gene ID: (Human) 834, (Human) 1357, (Human) 1452, (Human) 122011, (Mouse) 12362, (Rat) 113927, (Human) 8350, (Human) 4137, (Human) 142, (Human) 10383
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