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Invitrogen
UGT1A1 Recombinant Rabbit Monoclonal Antibody (8U9P3)
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FIGURE: 1 / 1
UGT1A1 Antibody (MA568887) in WB
Western blot analysis of UGT1A1 in various lysates. Samples were incubated with UGT1A1 Recombinant monoclonal antibody (Product # MA5-51266) using a dilution of 1:4,000 followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA568887
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
8U9P3
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.43 mg/mL
Amount
8.6 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: ENDSFLQRVI KTYKKIKKDS AMLLSGCSHL LHNKELMASL AESSFDVMLT DPFLPCSPIV AQYLSLPTVF FLHALPCSLE FEATQCPNPF SYVPRPLSSH
Target Information
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B1; Bilirubin-specific UDPGT isozyme 1; EC 2.4.1.17; HUG BR1; hUG-BR1; HUGBR1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1 family member 1; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1A isoform 1; UDP-glucuronosyltransferase 1A1; UDPGT 1-1; UGT 1A; UGT1 01; UGT1*1; UGT1-01; UGT1.1; UGT1A1
Gene Aliases: GNT1; Udpgt; UDPGT 1-1; UGT1; UGT1A1
UniProt ID: (Rat) Q64550
Entrez Gene ID: (Rat) 24861
liver development
bilirubin conjugation
acute-phase response
response to nutrient
metabolic process
flavonoid biosynthetic process
response to organic substance
response to organic cyclic compound
organ regeneration
response to lipopolysaccharide
cellular response to hormone stimulus
response to drug
response to starvation
negative regulation of catalytic activity
response to ethanol
response to steroid hormone
response to glucocorticoid
flavone metabolic process
flavonoid glucuronidation
xenobiotic glucuronidation
biphenyl catabolic process
cellular response to ethanol
cellular response to glucocorticoid stimulus
negative regulation of cellular glucuronidation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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