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Invitrogen
KRIT1 Recombinant Rabbit Monoclonal Antibody (25GB4350)
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图: 1 / 4
KRIT1 Antibody (MA570856) in ICC/IF
Immunocytochemistry analysis of KRIT1 in C2C12 cells. Sample was incubated with KRIT1 monoclonal antibody (Product # MA570855) at a dilution of 1:1,000. Nuclei were stained blue with DAPI and Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA570856
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
25GB4350
抗原
Recombinant protein of human KRIT1. The antigenic range is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.2 mg/mL
规格
24 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Dry ice (international)
靶标信息
This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cerebral cavernous malformations 1 protein; Cerebral cavernous malformations 1 protein homolog; Krev interaction trapped 1; Krev interaction trapped protein 1
基因别名: 2010007K12Rik; A630036P20Rik; AA432855; AI450393; AI643869; BB155247; BB235701; CCM1; KRIT1; RGD1305929
UniProt ID: (Mouse) Q6S5J6
Entrez Gene ID: (Rat) 362317, (Mouse) 79264
negative regulation of endothelial cell proliferation
biological_process
negative regulation of endothelial cell migration
negative regulation of angiogenesis
positive regulation of protein binding
cell redox homeostasis
regulation of establishment of cell polarity
negative regulation of endothelial cell apoptotic process
angiogenesis
regulation of catalytic activity
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
