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Invitrogen
PDE4D3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-31137
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to unique amino acid sequence on PDE4D3 variant.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.68 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris glycine, pH 7.4-7.9, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: Rat cortical membranes.
PA1-31137 does not cross react with PDE4D1, D2, D4 and D5. Does not cross react with PDE4A, PDE4B or PDE4C.
Target Information
PDE4D3 (Phosphodiesterase 4D, cAMP-specific, isoform 3) is an enzyme encoded by the PDE4D gene, which is located on chromosome 5. PDE4D3 belongs to the PDE4 family, which plays a crucial role in hydrolyzing cyclic AMP (cAMP), thereby regulating intracellular levels of this important signaling molecule. PDE4D3 is integral in modulating cAMP signaling pathways, impacting processes such as cardiac function and inflammation. This isoform of phosphodiesterase has been found to interact within a large protein complex, including Epac1, PKA, and ERK5, which is anchored by mAKAP. Phosphorylation by ERK decreases PDE4D3 activity, leading to local cAMP accumulation and increased activation of cAMP-dependent pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3',5'-cyclic AMP phosphodiesterase; alternatively spliced; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; cyclic AMP specific phosphodiesterase PDE4D5A; DKFZp686M11213; dunce; FLJ97311; HGNC:8783; HS PDE4DN2; PDE4D1; PDE4D10; PDE4D11; PDE4D2_v1; PDE4D2_v2; PDE4D2_v3; PDE4D3; PDE4D6; PDE4D7; phosphodiesterase 4D, cAMP-specific; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); splice variant PDE4D4; unnamed protein product
Gene Aliases: 9630011N22Rik; DPDE3; PDE3/IVd
UniProt ID: (Rat) P14270, (Mouse) Q01063
Entrez Gene ID: (Chicken) 769469, (Rat) 24627, (Mouse) 238871
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
calcium channel regulator activity
protein binding
phosphoric diester hydrolase activity
enzyme binding
receptor regulator activity
cAMP binding
beta-2 adrenergic receptor binding
ion channel binding
3',5'-cyclic-GMP phosphodiesterase activity
ATPase binding
scaffold protein binding
heterocyclic compound binding
phosphodiesterase
ovulation from ovarian follicle
positive regulation of protein phosphorylation
regulation of heart rate
cAMP catabolic process
smooth muscle contraction
signal transduction
memory
positive regulation of heart rate
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
positive regulation of smooth muscle cell migration
positive regulation of cell-cell adhesion
lung development
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-5 production
multicellular organism growth
negative regulation of heart contraction
positive regulation of smooth muscle cell proliferation
T cell receptor signaling pathway
leukocyte migration
establishment of endothelial barrier
protein-containing complex assembly
cellular response to lipopolysaccharide
cellular response to cAMP
cellular response to follicle-stimulating hormone stimulus
cellular response to epinephrine stimulus
adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
cAMP/PKA signal transduction
regulation of cAMP/PKA signal transduction
negative regulation of cAMP/PKA signal transduction
regulation of cell communication by electrical coupling involved in cardiac conduction
negative regulation of relaxation of cardiac muscle
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
regulation of G-protein coupled receptor protein signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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