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Invitrogen

mGluR1/mGluR5 Polyclonal Antibody

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View all (19) mGluR1/mGluR5 antibodies

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mGluR1/mGluR5 Polyclonal Antibody

Product Details

PA1-4663

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

1:500
-

Immunohistochemistry - Free Floating (IHC (Free))

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to the C-terminal region of rat GRM5 conjugated to KLH
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Amount

25 µg

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2115762

Product Specific Information

This antibody is predicted to react with human and mouse based on 100% sequence homology.

This antibody is specific for the ~125 kDa monomer and the ~250 kDa dimmers of mGluR5 and mGluR1 in Western blots of rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the peptide used to generate the antibody.

Target Information

may play a role in synaptic transmission; may interact with mGluR1, another group I metabotropic glutamate receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: G protein coupled receptor family C group 1 member A; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member E; glutamate receptor; glutamate receptor, metabotropic 1; glutamate receptor, metabotropic 5; metabotropic glutamate receptor (mGluR5); metabotropic glutamate receptor 5b; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; mGluR1; mGluR5; mGlurR1a; unnamed protein product; variant b of mGluR5

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Gene Aliases: 4930455H15Rik; 6430542K11Rik; Glu5R; Gm10828; Gprc1a; Gprc1e; mGluR1; mGluR5; mGluR5b; nmf373; rcw; wobl

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UniProt ID: (Rat) P23385, (Mouse) P97772, (Rat) P31424, (Mouse) Q3UVX5

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Entrez Gene ID: (Rat) 24414, (Mouse) 14816, (Rat) 24418, (Mouse) 108071

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Function(s)
PLC activating G-protein coupled glutamate receptor activity adenylate cyclase inhibiting G-protein coupled glutamate receptor activity fibronectin binding G-protein coupled receptor activity protein binding collagen binding glutamate receptor activity estrogen receptor binding laminin binding G protein-coupled neurotransmitter receptor activity G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential protein sequestering activity calmodulin binding PDZ domain binding protein tyrosine kinase activator activity A2A adenosine receptor binding identical protein binding protein tyrosine kinase binding
Process(es)
temperature homeostasis response to amphetamine desensitization of G-protein coupled receptor protein signaling pathway regulation of transcription, DNA-templated protein phosphorylation G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration phospholipase C-activating G-protein coupled glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway chemical synaptic transmission learning or memory learning locomotory behavior associative learning positive regulation of dopamine secretion operant conditioning protein targeting to nuclear inner membrane response to morphine positive regulation of MAPK cascade response to ethanol response to antibiotic phosphatidylinositol-mediated signaling regulation of long-term neuronal synaptic plasticity positive regulation of long-term neuronal synaptic plasticity modulation of synaptic transmission synapse organization positive regulation of calcium-mediated signaling cognition response to corticosterone regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential negative regulation of dendritic spine morphogenesis sensory perception of hot stimulus negative regulation of excitatory postsynaptic potential positive regulation of cellular response to hypoxia regulation of long term synaptic depression positive regulation of intracellular signal transduction positive regulation of sensory perception of pain cellular response to beta-amyloid conditioned place preference positive regulation of neural precursor cell proliferation regulation of glutamate secretion sensory perception of pain calcium-mediated signaling positive regulation of cell migration regulation of membrane potential negative regulation of viral entry into host cell receptor-mediated virion attachment to host cell membrane depolarization regulation of sensory perception of pain synaptic transmission, GABAergic cellular response to electrical stimulus L-glutamate import across plasma membrane synaptic signaling via neuropeptide negative regulation of protein localization to plasma membrane
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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