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Invitrogen
CYP1B1 Polyclonal Antibody
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CYP1B1 Antibody (PA5-95277) in IHC (P)
Immunohistochemistry analysis of CYP1B1 in paraffin-embedded human liver cancer tissue. Antigen retrieval was performed on the tissue using citrate buffer (pH 6, 20 min) and blocked with 10% goat serum. Samples were incubated with CYP1B1 polyclonal antibody (Product # PA5-95277) at a 1 µg/mL dilution, followed by biotinylated goat anti-rabbit IgG (30 min, 37°C), and developed with Strepavidin-Biotin-Complex... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-95277
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human CYP1B1 recombinant protein (Position: R255-L480).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Human CYP1B1 shares 85.4% and 84.5% amino acid (aa) sequence identity with mouse and rat CYP1B1, respectively.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human MCF-7 whole cell, human PC-3 whole cell, rat heart tissue, mouse heart tissue. IHC: Mouse Kidney tissue, Rat Kidney tissue, Human Liver Cancer tissue. Flow: SiHa cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
CYP1B1 is a 543 amino acid intracellular protein localized to the endoplasmic reticulum. It belongs to the cytochrome P450 super family of enzymes which are monooxygenases and it catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol and is also involved in the metabolism of substances active in the eye growth and differentiation and hence plays a putative role in ocular development. Mutated proteins are known to cause primary congenital glaucoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: benz[a]anthracene inducible; CYPIB1; Cytochrome P450 1B1; cytochrome P450, 1b1, benz[a]anthracene inducible; cytochrome P450, subfamily 1B, polypeptide 1; Cytochrome P450CMEF; Cytochrome P450EF; Cytochrome P450RAP; Hydroperoxy icosatetraenoate dehydratase; P450RAP
基因别名: CP1B; Cyp1-b1; Cyp1b1; P4501b1
UniProt ID: (Rat) Q64678, (Mouse) Q64429
Entrez Gene ID: (Rat) 25426, (Mouse) 13078
monooxygenase activity
iron ion binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
heme binding
aromatase activity
metal ion binding
oxidoreductase
oxygenase
metabolite interconversion enzyme
angiogenesis
trabecular meshwork development
DNA modification
cellular aromatic compound metabolic process
xenobiotic metabolic process
nitric oxide biosynthetic process
cell adhesion
response to nutrient
steroid metabolic process
estrogen metabolic process
negative regulation of cell proliferation
male gonad development
intrinsic apoptotic signaling pathway in response to oxidative stress
toxin metabolic process
response to toxic substance
response to organic substance
positive regulation of vascular endothelial growth factor production
response to organic cyclic compound
positive regulation of smooth muscle cell migration
dibenzo-p-dioxin metabolic process
arachidonic acid metabolic process
collagen fibril organization
adrenal gland development
negative regulation of cell migration
negative regulation of NF-kappaB transcription factor activity
response to follicle-stimulating hormone
response to estradiol
negative regulation of cell adhesion mediated by integrin
benzene-containing compound metabolic process
retinol metabolic process
retinal metabolic process
positive regulation of apoptotic process
endothelial cell migration
estrous cycle
positive regulation of translation
positive regulation of angiogenesis
positive regulation of JAK-STAT cascade
membrane lipid catabolic process
response to arsenic-containing substance
blood vessel morphogenesis
response to steroid hormone
oxidation-reduction process
retina vasculature development in camera-type eye
retinal blood vessel morphogenesis
ganglion development
cellular response to hydrogen peroxide
cellular response to cAMP
cellular response to tumor necrosis factor
cellular response to luteinizing hormone stimulus
cellular response to cortisol stimulus
cellular response to progesterone stimulus
cellular response to organic cyclic compound
response to dexamethasone
endothelial cell-cell adhesion
response to indole-3-methanol
regulation of reactive oxygen species metabolic process
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process
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