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Invitrogen
CYP17A1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-95393
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human CYP17A1 (383-419aa EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL once reconstituted
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.01mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human SH-SY5Y whole cell, human HepG2 whole cell, human Hela whole cell, human Jurkat whole cell, rat testis tissue. IHC: human testis tissue. Flow: U87 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 17-alpha hydroxylase; 17-alpha-hydroxyprogesterone aldolase; 17a-hydroxylase; CYPXVII; cytochrom P450c17 (EC 1.14.99.9); cytochrome P-450c17; cytochrome P-450c17 (EC 1.14.99.9); cytochrome P450 17A1; cytochrome p450 XVIIA1; cytochrome P450, family 17, subfamily A, polypeptide 1; cytochrome P450, subfamily 17; Cytochrome P450, subfamily XVII; cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia; cytochrome P450-C17; cytochrome P450c17; HGNC:2593; P-450 17-alpha protein; P450-C17; P45017alpha; P450c17; steroid 17-alpha-monooxygenase; unnamed protein product
Gene Aliases: CPT7; CYP17; P450C17; S17AH
UniProt ID: (Human) P05093, (Rat) P11715
Entrez Gene ID: (Human) 1586, (Rat) 25146
monooxygenase activity
steroid 17-alpha-monooxygenase activity
iron ion binding
steroid hydroxylase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
oxygen binding
heme binding
steroid biosynthetic process
androgen biosynthetic process
glucocorticoid biosynthetic process
steroid metabolic process
male gonad development
response to xenobiotic stimulus
response to bacterium
response to herbicide
response to toxic substance
response to acetate
response to ionizing radiation
response to insecticide
hippocampus development
adrenal gland development
response to nutrient levels
response to retinoic acid
Leydig cell differentiation
response to cytokine
cortisol biosynthetic process
response to gonadotropin
hormone biosynthetic process
progesterone metabolic process
response to steroid hormone
response to cAMP
response to methylmercury
response to fungicide
cellular response to lipopolysaccharide
cellular response to antibiotic
cellular response to gonadotropin stimulus
positive regulation of steroid hormone biosynthetic process
response to 2,3,7,8-tetrachlorodibenzodioxine
sex differentiation
primary alcohol metabolic process
hormone metabolic process
olefinic compound metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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