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Invitrogen
Caspase 4 Polyclonal Antibody
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图: 1 / 7
Caspase 4 Antibody (PA5-95498) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of Caspase 4 in A431 cell using Caspase 4 Polyclonal Antibody (Product # PA5-95498). Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and incubated with the primary antibody at 2 µg/mL. DyLight 488 conjugated goat anti-rabbit IgG was used as secondary antibody at 1:100 dil... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-95498
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human Caspase 4 recombinant protein (Position: H111-R194).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human COLO-320 whole cell, human SW620 whole cell, human HepG2 whole cell. IHC: human colon cancer tissue, human mammary cancer tissue. ICC/IF: A431 cell. Flow: SiHa cell, PC-3 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: apoptotic cysteine protease Mih1/TX; CASP-4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-4; ICE and Ced-3 homolog 2; ICE(rel)-II; ICH-2; Mih1; propeptide of Mih1/TX; protease ICH-2; Protease TX; unnamed protein product
基因别名: CASP-4; CASP4; ICE(rel)II; ICEREL-II; ICH-2; ICH2; Mih1; Mih1/TX; TX
Entrez Gene ID: (Human) 837
proteolysis
apoptotic process
protein autoprocessing
defense response to bacterium
regulation of apoptotic process
positive regulation of neuron apoptotic process
regulation of inflammatory response
positive regulation of inflammatory response
defense response to Gram-positive bacterium
protein maturation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
pyroptosis
intrinsic apoptotic signaling pathway
non-canonical inflammasome complex assembly
positive regulation of tumor necrosis factor-mediated signaling pathway
cellular response to beta-amyloid
positive regulation of interleukin-18-mediated signaling pathway
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
