Search
Invitrogen
MRE11 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
图: 1 / 4
MRE11 Antibody (PA5-95501) in IHC (P)
Immunohistochemistry analysis of MRE11 in paraffin-embedded human mammary cancer tissue. Antigen retrieval was performed on the tissue using citrate buffer (pH 6, 20 min) and blocked with 10% goat serum. Samples were incubated with MRE11 polyclonal antibody (Product # PA5-95501) at a 1 µg/mL dilution, followed by biotinylated goat anti-rabbit IgG (30 min, 37°C), and developed with Strepavidin-Biotin-Complex... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-95501
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human MRE11 recombinant protein (Position: S2-D239).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human MCF-7 whole cell, human COLO-320 whole cell, human U-87MG whole cell, rat brain tissue, rat liver tissue, mouse brain tissue, mouse liver tissue. IHC: human colon cancer tissue, human lung cancer tissue, human mammary cancer tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex. This complex plays a central role in double-strand break repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-stranded endonuclease activity and double-strand-specific 3'-5' exonuclease activity which are provided by MRE11. RAD50 is required to bind DNA ends and hold them in close proximity. Mutations in the gene could result in ataxia-telangiectasia-like disorder 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Double-strand break repair protein MRE11; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; Meiotic recombination 11 homolog A; mmMRE11A; MRE11 homolog 1; MRE11 homolog A
基因别名: Mre11; Mre11a; Mre11b
UniProt ID: (Rat) Q9JIM0, (Mouse) Q61216
Entrez Gene ID: (Rat) 64046, (Mouse) 17535
DNA binding
ATP-dependent DNA helicase activity
endonuclease activity
exonuclease activity
protein binding
protein C-terminus binding
3'-5' exonuclease activity
manganese ion binding
single-stranded DNA endodeoxyribonuclease activity
nuclease activity
endodeoxyribonuclease activity
hydrolase activity
telomere maintenance
base-excision repair
nucleotide-excision repair
double-strand break repair
cellular response to DNA damage stimulus
sister chromatid cohesion
mitotic G2 DNA damage checkpoint
synapsis
heart development
cell proliferation
intra-S DNA damage checkpoint
positive regulation of protein autophosphorylation
DNA duplex unwinding
negative regulation of DNA endoreduplication
positive regulation of kinase activity
negative regulation of viral entry into host cell
chromosome organization
meiotic cell cycle
nucleic acid phosphodiester bond hydrolysis
DNA metabolic process
DNA repair
double-strand break repair via nonhomologous end joining
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
