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Invitrogen
PTPRU Polyclonal Antibody
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FIGURE: 1 / 3
PTPRU Antibody (PA5-100028) in ICC/IF
Immunofluorescent analysis of PTPRU in HepG2. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C) incubated with PTPRU polyclonal antibody (Product # PA5-100028) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 at a dilution of 1:600.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-100028
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PTPRU(Accession Q92729), corresponding to amino acid residues K343-A393.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PTPRU.
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GLEPP1; Pancreatic carcinoma phosphatase 2; pi R-PTP-Psi; protein tyrosine phosphatase, receptor type, L; protein-tyrosine phosphatase J; protein-tyrosine phosphatase pi; protein-tyrosine phosphatase receptor omicron; Protein-tyrosine phosphatase-lamda; PTP pi; R-ptp-psi; Receptor protein tyrosine phosphatase hPTP-J; Receptor-type protein-tyrosine phosphatase psi; unnamed protein product
Gene Aliases: FMI; Ftp-1; hPTP-J; PCP-2; Pcp2; PTP; PTP-J; PTP-lambda; PTP-PI; PTP-RO; Ptpf; PTPlambda; PTPPSI; Ptprl; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U; RPTPlambda
UniProt ID: (Human) Q92729, (Mouse) B1AUH1
Entrez Gene ID: (Human) 10076, (Mouse) 19273, (Rat) 116680
protein dephosphorylation
cell adhesion
signal transduction
transmembrane receptor protein tyrosine phosphatase signaling pathway
negative regulation of cell proliferation
negative regulation of cell migration
organ regeneration
neuron projection development
protein localization to cell surface
response to glucocorticoid
negative regulation of canonical Wnt signaling pathway
positive regulation of cell-cell adhesion mediated by cadherin
homotypic cell-cell adhesion
neuron differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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