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Invitrogen
Cytochrome P450 Pan Polyclonal Antibody
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FIGURE: 1 / 2
Cytochrome P450 Pan Antibody (PA5-101312) in ICC/IF
Immunocytochemistry analysis of Cytochrome P450 Pan in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Cytochrome P450 Pan polyclonal antibody (Product # PA5-101312) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor4... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-101312
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CYP2C18(Accession P33260), corresponding to amino acid residues N116-P166.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Cytochrome P450 2C8/9/18/19.
Target Information
CYP2C9 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP2C9 localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; (S)-mephenytoin hydroxylase associated cytochrome P450; 4-nitrophenol 2-hydroxylase; CYPIIC18; CYPIIE1; cytochrome P-450 1; cytochrome P-450 II C; cytochrome P-450 S-mephenytoin 4-hydroxylase; cytochrome P-450MP; cytochrome P450 form 1; cytochrome P450 IIC2; cytochrome P450 MP-12; cytochrome P450 MP-20; cytochrome P450 PB-1; cytochrome P450, 2e1, ethanol inducible; cytochrome P450, family 2, subfamily C, polypeptide 18; cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, family 2, subfamily C, polypeptide 9; cytochrome P450, family 2, subfamily E, polypeptide 1; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1; cytochrome P450-11A; cytochrome P450-254C; cytochrome P450-6B/29C; cytochrome P450-ALC; cytochrome P450-J; cytochrome P450A; cytochrome P450j; fenbendazole monooxygenase (4'-hydroxylating); flavoprotein-linked monooxygenase; IIC2; mephenytoin 4'-hydroxylase; mephenytoin 4-hydroxylase; microsomal monooxygenase; microsomal monooxygenase; xenobiotic monooxygenase; mouse Cyp2e1; P450 form 1; S-mephenytoin 4-hydroxylase; unnamed protein product; unspecific monooxygenase; xenobiotic monooxygenase
Gene Aliases: CPC8; CPC9; CPCI; CPCJ; CPE1; CYP2C; CYP2C10; CYP2C17; CYP2C8DM; CYP2E; CYPIIC17; CYPIIC19; CYPIIC8; CYPIIC9; CYPIIE1; MP-12/MP-20; P450-2C9; P450-6B/29C; P450-J; P450C2C; P450C2E; P450IIC17; P450IIC19; P450IIC9
UniProt ID: (Human) P33260, (Human) P33261, (Human) P10632, (Human) P11712, (Human) P05181, (Mouse) Q05421
Entrez Gene ID: (Human) 1562, (Human) 1557, (Human) 1558, (Human) 1559, (Human) 1571, (Mouse) 13106
monooxygenase activity
iron ion binding
arachidonic acid epoxygenase activity
retinoic acid 4-hydroxylase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
oxygen binding
heme binding
linoleic acid epoxygenase activity
steroid hydroxylase activity
arachidonic acid 14,15-epoxygenase activity
arachidonic acid 11,12-epoxygenase activity
oxidoreductase activity
(S)-limonene 6-monooxygenase activity
(S)-limonene 7-monooxygenase activity
enzyme binding
(R)-limonene 6-monooxygenase activity
arachidonate 8,9-epoxygenase activity
long-chain fatty acid omega-1 hydroxylase activity
fatty acid omega-1 hydroxylase activity
protein binding
caffeine oxidase activity
estrogen 16-alpha-hydroxylase activity
estrogen 2-hydroxylase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
4-nitrophenol 2-monooxygenase activity
Hsp70 protein binding
Hsp90 protein binding
long-chain fatty acid metabolic process
fatty acid metabolic process
terpenoid metabolic process
xenobiotic metabolic process
steroid metabolic process
monoterpenoid metabolic process
epoxygenase P450 pathway
monocarboxylic acid metabolic process
xenobiotic catabolic process
omega-hydroxylase P450 pathway
cholesterol metabolic process
estrogen metabolic process
arachidonic acid metabolic process
urea metabolic process
long-chain fatty acid biosynthetic process
icosanoid biosynthetic process
oxidative demethylation
cellular organofluorine metabolic process
lipid hydroxylation
triglyceride metabolic process
response to bacterium
4-nitrophenol metabolic process
carbon tetrachloride metabolic process
benzene metabolic process
halogenated hydrocarbon metabolic process
retinol metabolic process
retinoic acid metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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