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Invitrogen
ACER2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-101415
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ACER2(Accession Q5QJU3), corresponding to amino acid residues Y209-P259.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ASAH3L.
Target Information
The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alkaline CDase 2; alkCDase 2; cancer related gene-liver 1 (CRG-L1); cancer-related gene liver 1 protein; ceramide hydrolase; CRG-L1; haCER2; unnamed protein product
Gene Aliases: 2410116I05Rik; ALKCDase2; ASAH3L; CRG-L1; maCER2
UniProt ID: (Human) Q5QJU3, (Mouse) Q8VD53
Entrez Gene ID: (Human) 340485, (Mouse) 230379
negative regulation of cell-matrix adhesion
sphingolipid metabolic process
ceramide metabolic process
cellular response to DNA damage stimulus
positive regulation of cell proliferation
regulation of autophagy
regulation of glycoprotein biosynthetic process
sphingolipid catabolic process
DNA damage response, signal transduction by p53 class mediator
response to retinoic acid
negative regulation of cell adhesion mediated by integrin
regulation of apoptotic process
sphingosine biosynthetic process
ceramide catabolic process
cellular response to xenobiotic stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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