Invitrogen

SLC16A2 Polyclonal Antibody

Name: SLC16A2 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-101676
Availability: InStock

查看其他6个SLC16A2抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (3)

SLC16A2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 3

SLC16A2 Antibody (PA5-101676) in IHC (P)

Immunohistochemistry analysis of SLC16A2 in mouse liver tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with SLC16A2 polyclonal antibody (Product # PA5-101676) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

Product Image Gallery

Immunogen image

Immunogen Image SLC16A2 Polyclonal Antibody

产品信息

PA5-101676

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:100-1:500

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human SLC16A2(Accession P36021), corresponding to amino acid residues N111-V161.

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

100 µg

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2851110

产品详细信息

Antibody detects endogenous levels of total SLC16A2.

靶标信息

Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT 1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. Defects in the gene encoding for MCT8, SLC16A2, can cause monocarboxylate transporter 8 deficiency (MCT8 deficiency), a defect in cellular hormone transport causing a severe form of X-linked psychomotor retardation and abnormal thyroid levels.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: MCT 7; MCT 8; monocarboxylate transporter; Monocarboxylate transporter 7; Monocarboxylate transporter 8; Monocarboxylate transporter 8 (MCT 8) (X-linked PEST-containing transporter); solute carrier family 16 (monocarboxylic acid transporters), member 2; Solute carrier family 16 member 2; solute carrier family 16, member 2 (monocarboxylic acid transporter 8); solute carrier family 16, member 2 (thyroid hormone transporter); X-linked PEST-containing transporter

查看更多收起

基因别名: AHDS; AW105741; DXS128; DXS128E; MCT 7; MCT 8; MCT7; MCT8; MRX22; SLC16A2; XPCT

查看更多收起

UniProt ID: (Rat) Q8K1P8, (Mouse) O70324

查看更多收起

Entrez Gene ID: (Human) 6567, (Rat) 259248, (Mouse) 20502

查看更多收起

功能

protein binding monocarboxylic acid transmembrane transporter activity amino acid transmembrane transporter activity thyroid hormone transmembrane transporter activity transmembrane transporter activity identical protein binding carboxylic acid transmembrane transporter activity symporter activity transporter

参与通路