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Invitrogen
MTNR1B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-102107
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MTNR1B(Accession P49286), corresponding to amino acid residues S6-V56.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total MTR1B.
靶标信息
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Mel-1B-R; mel1b melatonin receptor; mel1b receptor; Melatonin receptor type 1B
基因别名: Mel1b-r; Mt2; MTNR1B
UniProt ID: (Rat) P49287
Entrez Gene ID: (Rat) 192646
G-protein coupled receptor signaling pathway
negative regulation of cGMP metabolic process
glucose homeostasis
positive regulation of circadian rhythm
camera-type eye development
negative regulation of neuron apoptotic process
positive regulation of vasodilation
positive regulation of circadian sleep/wake cycle, non-REM sleep
negative regulation of insulin secretion
regulation of insulin secretion
negative regulation of cytosolic calcium ion concentration
negative regulation of transmission of nerve impulse
positive regulation of transmission of nerve impulse
regulation of neuronal action potential
negative regulation of delayed rectifier potassium channel activity
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