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Invitrogen
MTM1 Polyclonal Antibody
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FIGURE: 1 / 3
MTM1 Antibody (PA5-102308) in IHC (P)
Immunohistochemistry analysis of MTM1 in human kidney cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with MTM1 polyclonal antibody (Product # PA5-102308) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-102308
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MTM1(Accession Q13496), corresponding to amino acid residues R570-F603.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MTM1.
Target Information
Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Myotubularin; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase; X-linked myotubular myopathy gene 1
Gene Aliases: AF073996; CG2; mKIAA4176; Mtm; MTM1
UniProt ID: (Rat) Q6AXQ4, (Mouse) Q9Z2C5
Entrez Gene ID: (Rat) 288762, (Mouse) 17772
molecular_function
phosphatidylinositol-3-phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
intermediate filament binding
phosphatidylinositol binding
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
protein binding
hydrolase activity
phosphatase activity
phosphatase
protein dephosphorylation
biological_process
endosome to lysosome transport
protein transport
peptidyl-tyrosine dephosphorylation
regulation of vacuole organization
intermediate filament organization
muscle cell cellular homeostasis
phosphatidylinositol dephosphorylation
mitochondrion distribution
mitochondrion morphogenesis
lipid metabolic process
transport
dephosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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