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Invitrogen
NUAK2 Polyclonal Antibody
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NUAK2 Antibody (PA5-102344) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded NUAK2 in human gastric tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with NUAK2 polyclonal antibody (Product # PA5-102344) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-102344
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NUAK2(Accession Q9H093), corresponding to amino acid residues G246-D296.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total NUAK2.
靶标信息
NUAK2 or SNF1/AMP kinase-related kinase (SNARK) is a member of the NUAK family of SNF1-like kinase 2. NUAK2 is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle (1). NUAK2 is involved in cellular stress responses linked to obesity and type 2 diabetes. NUAK2 shows kinase activity against a synthetic test peptide and the activity in keratinocytes is increased by AMP and 5-amino-4-imidazolecarboxamide riboside, implying that AMPK kinase-dependent pathway can activate NAUK2. Glucose deprivation also increases NAUK2 activity in baby hamster kidney fibroblasts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: NUAK family SNF1-like kinase 2; nuak2; nuak2 {ECO:0000312|EMBL:AAH81899.1}; Omphalocele kinase 2; SNARK; SNF1/AMP kinase-related kinase; SNF1/AMP-activated protein kinase
基因别名: 1200013B22Rik; mKIAA0537; NUAK2; OMPHK2; SNARK; UV126
UniProt ID: (Mouse) Q8BZN4, (Rat) Q66HE5
Entrez Gene ID: (Mouse) 74137, (Rat) 289419
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