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Invitrogen
SERCA2 ATPase Polyclonal Antibody
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FIGURE: 1 / 2
SERCA2 ATPase Antibody (PA5-102354) in ICC/IF
Immunocytochemistry analysis of SERCA2 ATPase in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with SERCA2 ATPase polyclonal antibody (Product # PA5-102354) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conj... View More
Product Details
PA5-102354
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ATP2A2(Accession P16615), corresponding to amino acid residues I638-E688.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ATP2A2.
Target Information
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; ATPase, Ca++ transporting, slow twitch 2; calcium ATPase; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; cardiac Ca2+ ATPase; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; HK1; HK2; sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2; sarco/endoplasmic reticulum Ca2+-ATPase 2; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA; SERCA ATPase; SERCA2; SR Ca(2+)-ATPase 2; unnamed protein product
Gene Aliases: 9530097L16Rik; ATP2A2; ATP2B; D5Wsu150e; DAR; DD; mKIAA4195; RHABDO2; SERCA2; Serca2a; SERCA2B; SercaII
UniProt ID: (Human) P16615, (Mouse) O55143, (Rat) P11507
Entrez Gene ID: (Human) 488, (Mouse) 11938, (Rat) 29693
nucleotide binding
calcium channel regulator activity
calcium-transporting ATPase activity
calcium ion binding
protein binding
ATP binding
ATPase activity
enzyme binding
ion channel binding
S100 protein binding
metal ion binding
calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential
lncRNA binding
protein C-terminus binding
hydrolase activity
lutropin-choriogonadotropic hormone receptor binding
primary active transporter
autophagosome assembly
regulation of the force of heart contraction
muscle system process
ion transport
calcium ion transport
cellular calcium ion homeostasis
regulation of muscle contraction
ER-nucleus signaling pathway
cell adhesion
epidermis development
positive regulation of heart rate
positive regulation of cardiac muscle cell apoptotic process
regulation of cardiac muscle contraction by calcium ion signaling
transition between fast and slow fiber
cardiac muscle hypertrophy in response to stress
autophagosome membrane docking
endoplasmic reticulum calcium ion homeostasis
positive regulation of endoplasmic reticulum calcium ion concentration
T-tubule organization
ion transmembrane transport
cellular response to oxidative stress
response to endoplasmic reticulum stress
negative regulation of heart contraction
relaxation of cardiac muscle
neuron cellular homeostasis
sarcoplasmic reticulum calcium ion transport
calcium ion transmembrane transport
regulation of cardiac muscle cell membrane potential
regulation of cardiac muscle cell action potential involved in regulation of contraction
organelle localization by membrane tethering
regulation of calcium ion-dependent exocytosis of neurotransmitter
calcium ion transport from cytosol to endoplasmic reticulum
regulation of cardiac conduction
calcium ion import into sarcoplasmic reticulum
mitochondrion-ER tethering
transport
organelle organization
response to peptide hormone
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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