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Invitrogen
Uteroglobin Polyclonal Antibody
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FIGURE: 1 / 5
Uteroglobin Antibody (PA5-102469) in ICC/IF
Immunofluorescent analysis of Uteroglobin in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Uteroglobin polyclonal antibody (Product # PA5-102469) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-102469
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SCGB1A1(Accession P11684), corresponding to amino acid residues A45-N91.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SCGB1A1.
Target Information
Uteroglobin, which is a member of the Secretoglobin superfamily and is also known as Clara cell phospholipid-binding protein, is a multifunctional protein that can exert anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. The small, non-glycosylated protein named for its high levels of expression in pre-implantation embryos, where it exhibits growth stimulatory effects, is produced and secreted by the non-ciliated, non-mucous Clara cells predominant in the epithelial surfaces of pulmonary airways, as well as other non-ciliated epithelia. Members of the Secretoglobin superfamily demonstrate a high level of structural conservation and are characterized as small, secretory homo- or heterodimers. In addition to sequestering pro-inflammatory mediators and carcinogens, Uteroglobin has been implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Blastokinin; CC10; CCPBP; clara cell 17 kDa protein; clara cell phospholipid-binding protein; clara cell secretory protein; clara cells 10 kDa secretory protein; club cell 10 kDa secretory protein; Club cell 17 kDa protein; Club cell phospholipid-binding protein; club cell protein 16; Club cells 10 kDa secretory protein; club secretory protein 16; PCB-binding protein; SCGB1A1; Secretoglobin family 1A member 1; secretoglobin family 1A member 1 (uteroglobin) isoform SCGB1A1_1; secretoglobin family 1A member 1 (uteroglobin) isoform SCGB1A1_2; secretoglobin, family 1A, member 1 (uteroglobin); unnamed protein product; UP-1; Urinary protein 1; urine protein 1; Uteroglobin; Uteroglobin (Clara cell secretory protein); Uteroglobin (club-cell specific 10-kD protein)
Gene Aliases: CC10; CC16; CCPBP; CCSP; PCB-BP; PCBB; SCGB1A1; UG; UGB; UP-1; UP1; Utg
UniProt ID: (Mouse) Q06318, (Rat) P17559
Entrez Gene ID: (Human) 7356, (Mouse) 22287, (Rat) 25575
signal transduction
female pregnancy
embryo implantation
response to xenobiotic stimulus
response to ozone
response to lipopolysaccharide
response to silicon dioxide
response to cytokine
response to glucocorticoid
response to fibroblast growth factor
negative regulation of transcription from RNA polymerase II promoter
negative regulation of interferon-gamma production
negative regulation of interleukin-13 production
negative regulation of interleukin-4 production
negative regulation of interleukin-5 production
negative regulation of T cell proliferation
regulation of mRNA stability
regulation of inflammatory response
response to organic substance
response to drug
negative regulation of catalytic activity
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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