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Invitrogen
CDH23 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-102659
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CDH23(Accession Q9H251), corresponding to amino acid residues K445-V495.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CDH23.
Target Information
This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Alternative splice variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: age related hearing loss 1; bobby; bustling; Cadherin; cadherin 23; cadherin 23 (otocadherin); cadherin-23-like; cadherin-like 23; cadherin-related family member 23; DFNB12; DKFZp434P2350; FLJ00233; FLJ36499; member of cadherin superfamily; MGC102761; modifier of deaf waddler; otocadherin; OTTHUMP00000044780; unnamed protein product; USH1H; waltzer; Waltzing
Gene Aliases: 4930542A03Rik; ahl; ahl1; bob; bus; CDHR23; mdfw; nmf112; nmf181; nmf252; PITA5; sals; USH1D; v
UniProt ID: (Human) Q9H251, (Mouse) Q99PF4, (Rat) P58365
Entrez Gene ID: (Human) 64072, (Mouse) 22295, (Rat) 114102
calcium ion transport
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
sensory perception of sound
locomotory behavior
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell migration
neuron projection development
inner ear morphogenesis
auditory receptor cell differentiation
photoreceptor cell maintenance
inner ear development
sensory perception of light stimulus
equilibrioception
regulation of cytosolic calcium ion concentration
auditory receptor cell stereocilium organization
inner ear receptor stereocilium organization
cochlea development
cell-cell adhesion
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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