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Invitrogen
MVK Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-102745
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MVK(Accession Q03426), corresponding to amino acid residues A155-N205.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MVK.
Target Information
Mevalonate kinase (MVK) is an early enzyme in isoprenoid and sterol synthesis. Mevalonate kinase catalyzes the ATP-dependent phosphorylation of mevalonic acid to form mevalonate 5-phosphate. Deficiency in MVK activity contributes to mevalonic aciduria and hyperimmunoglobulinemia D/periodic fever syndrome (HIDS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KIME; LHR mRNA binding protein; Mevalonate kinase; MK
Gene Aliases: 2310010A05Rik; AI256848; AI414037; Lrbp; MK; MVK
UniProt ID: (Mouse) Q9R008, (Rat) P17256
Entrez Gene ID: (Mouse) 17855, (Rat) 81727
cholesterol biosynthetic process
isoprenoid metabolic process
isoprenoid biosynthetic process
sterol metabolic process
phosphorylation
negative regulation of translation
isopentenyl diphosphate biosynthetic process, mevalonate pathway
regulation of cholesterol biosynthetic process
negative regulation of inflammatory response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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