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Invitrogen
Cullin 5 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-102750
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CUL5(Accession Q93034), corresponding to amino acid residues A375-L425.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CUL5.
Target Information
CUL5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. It seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein and may form a cell surface vasopressin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CUL-5; Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1); SCF complex component; unnamed protein product; VACM-1; vasopressin-activated calcium-mobilizing receptor 1; vasopressin-activated calcium-mobilizing receptor protein; Vasopressin-activated calcium-mobilizing receptor-1
Gene Aliases: 4921514I20Rik; 8430423K24Rik; C030032G03Rik; C330021I08Rik; CUL-5; VACM-1; VACM1
UniProt ID: (Human) Q93034, (Rat) Q9JJ31, (Mouse) Q9D5V5
Entrez Gene ID: (Human) 8065, (Rat) 64624, (Mouse) 75717
protein polyubiquitination
ubiquitin-dependent protein catabolic process
signal transduction
G-protein coupled receptor signaling pathway
cell migration
protein ubiquitination
cerebral cortex radially oriented cell migration
radial glia guided migration of Purkinje cell
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
reelin-mediated signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of cytosolic calcium ion concentration
negative regulation of focal adhesion assembly
protein K11-linked ubiquitination
negative regulation of focal adhesion disassembly
regulation of neuron migration
G1/S transition of mitotic cell cycle
proteasomal protein catabolic process
positive regulation of cell migration
ERBB2 signaling pathway
calcium ion transmembrane transport
intrinsic apoptotic signaling pathway
epithelial to mesenchymal transition
negative regulation of epithelial to mesenchymal transition
protein catabolic process
endoplasmic reticulum unfolded protein response
erythropoietin-mediated signaling pathway
innate immune response
defense response to virus
positive regulation of focal adhesion assembly
symbiont-mediated suppression of host innate immune response
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
negative regulation of growth hormone receptor signaling pathway
protein K48-linked ubiquitination
cGAS/STING signaling pathway
negative regulation of cGAS/STING signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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