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Invitrogen
GFR alpha-1 Polyclonal Antibody
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FIGURE: 1 / 2
GFR alpha-1 Antibody (PA5-102752) in IHC (P)
Immunohistochemistry analysis of GFR alpha-1 in rat brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with GFR alpha-1 polyclonal antibody (Product # PA5-102752) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-102752
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GFRA1(Accession P56159), corresponding to amino acid residues S349-Q399.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total GFRA1.
Target Information
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFR-a-1 recently. GFR-a-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFR-a and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp313E1012; DKFZp686J0156; FLJ10561; FLJ31546; GDNF family receptor alpha-1; GDNF receptor alpha; GDNF receptor alpha 1d; GDNF receptor alpha 1e; GDNF receptor alpha-1; GDNFR-alpha; GDNFR-alpha-1; gfr alpha 1; GFR alpha-1; GFR-alpha-1; glial cell line derived neurotrophic factor family receptor alpha 1; Glial cell line-derived neurotrophic factor receptor alpha; GPI-linked anchor protein; GPI-linked receptor; MGC23045; PI-linked cell-surface accessory protein; RET ligand 1; similar to GDNF Receptor alpha; TGF-beta-related neurotrophic factor receptor 1; unnamed protein product
Gene Aliases: AU042498; GDNFR; GDNFR-alpha-1; GDNFRA; GFR-ALPHA-1; GFRA1; GFRalpha-1; RET1L; RETL1; RHDA4; TRNR1
UniProt ID: (Human) P56159, (Rat) Q62997, (Mouse) P97785
Entrez Gene ID: (Human) 2674, (Rat) 25454, (Mouse) 14585
kidney development
cell surface receptor signaling pathway
nervous system development
male gonad development
cell migration
neuron differentiation
neuron projection development
glial cell-derived neurotrophic factor receptor signaling pathway
neurotrophin signaling pathway
aging
transmembrane receptor protein tyrosine kinase signaling pathway
anatomical structure morphogenesis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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