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Invitrogen
NKp46 Polyclonal Antibody
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FIGURE: 1 / 6
NKp46 Antibody (PA5-102860) in WB
Western blot was performed using Anti-NKp46 Polyclonal Antibody (Product # PA5-102860) and a 46 kDa band corresponding to Natural cytotoxicity triggering receptor 1 was observed in NK-92 cells which was upregulated upon serum starvation followed by Human IL-2 treatment. Membrane enriched extracts (30 µg lysate) of NK-92 (Lane 1), NK-92 treated with Human IL-2 (20 ng/mL for 24h) (Lane 2) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-102860
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NCR1(Accession O76036), corresponding to amino acid residues C144-Y194.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total NCR1.
Target Information
CD335, also known as NKp46 or NCR1, is a member of the natural cytotoxicity receptor family, which includes NKp30 and NKp44. This type I transmembrane glycoprotein is expressed on NK cells and plays a crucial role in activating and expanding resting NK cells through interactions with dendritic cells. CD335 enhances the ability of NK cells to eliminate tumor and virus-infected cells, such as those infected by influenza. CD335 consists of two Ig-like domains and is related to leukocyte immunoglobulin-like receptors (LIR) and killer inhibitory receptors (KIR). It contributes to the increased efficiency of activated NK cells in mediating tumor cell lysis. Additionally, CD335 interacts with pancreatic beta cells during the development of type 1 diabetes, highlighting its involvement in both immune defense and autoimmune processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 1-Mar; activating receptor 1; hNKp46; Ly-94; lymphocyte antigen 94; lymphocyte antigen 94 homolog (activating NK-receptor; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); mAR-1; MAR1 (mouse activating receptor 1); mNKp46; natural killer cell p46-related protein; natural killer cell receptor; NK cell-activating receptor; NK receptor KILR-1; NK-p46; NK-p46); NKACTR; rAR-1; rat-activating receptor 1; type 1 one-pass transmembrane Ig-like protein; unnamed protein product
Gene Aliases: CD335; KILR-1; LY94; NK-p46; NKP46
UniProt ID: (Human) O76036, (Mouse) Q8C567, (Rat) Q9Z0H5
Entrez Gene ID: (Human) 9437, (Mouse) 17086, (Rat) 117547
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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