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Invitrogen
SPTBN1 Polyclonal Antibody
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SPTBN1 Antibody (PA5-103063) in ICC/IF
Immunocytochemistry analysis of SPTBN1 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with SPTBN1 polyclonal antibody (Product # PA5-103063) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-103063
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SPTBN1(Accession Q01082), corresponding to amino acid residues M1-D50.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total SPTBN1.
靶标信息
Spectrin (Sp), the most abundant of the erythrocyte membrane skeleton proteins, helps these cells maintain their characteristic biconcave shape while remaining flexible and elastic. Erythrocyte Sp is a heterodimer composed of a 280 kDa alpha subunit and a 246 kDa beta subunit which associate in a side-to-side, antiparallel configuration to form a 100 nm rod-like structure. Sp in other tissues may be composed of distinct but homologous alpha and beta subunits, sometimes referred to as fodrin. A newly introduced nomenclature designates the Sp subunits of the erythrocyte as alpha-1 and beta-1, and the fodrin subunits as alpha-2 and beta-2. Alternatively spliced forms of each are designated as epsilon-1, epsilon-2, etc. (e. g. beta-1 epsilon-1).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: beta fodrin; beta II spectrin-like (short form); Beta-II spectrin; beta-spectrin 2, non-erythrocytic; brain spectrin; bSPII-; cytoskeleton protein; Embryonic liver fodrin; embryonic liver fodrin beta chain; Fodrin beta chain; non-erythrocytic; non-erythroid spectrin beta; short form of beta II spectrin; spectrin beta 2; spectrin beta chain, brain 1; Spectrin beta chain, non-erythrocytic 1; spectrin G; Spectrin, non-erythroid beta chain 1
基因别名: 9930031C03Rik; AL033301; Elf; elf1; elf3; mKIAA4049; Spnb-2; Spnb1; Spnb2; SPTB2; SPTBN1
UniProt ID: (Mouse) Q62261
Entrez Gene ID: (Rat) 305614, (Mouse) 20742
mitotic cytokinesis
plasma membrane organization
common-partner SMAD protein phosphorylation
SMAD protein import into nucleus
Golgi to plasma membrane protein transport
membrane assembly
protein targeting to plasma membrane
actin filament capping
positive regulation of interleukin-2 secretion
regulation of protein localization to plasma membrane
positive regulation of protein localization to plasma membrane
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