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Invitrogen

NF1 Polyclonal Antibody

View all (11) NF1 antibodies

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NF1 Polyclonal Antibody

Product Details

PA5-103218

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NF1(Accession P21359), corresponding to amino acid residues S2802-V2839.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2852585

Product Specific Information

Antibody detects endogenous levels of total NF1.

Target Information

The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp686J1293; FLJ21220; neurofibromatosis 1; Neurofibromatosis type 1; neurofibromatosis-related protein NF-1; unnamed protein product

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Gene Aliases: Dsk9; E030030H24Rik; Mhdadsk9; Nf-1; NFNS; VRNF; WSS

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UniProt ID: (Human) P21359, (Rat) P97526, (Mouse) Q04690

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Entrez Gene ID: (Human) 4763, (Rat) 24592, (Mouse) 18015

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Function(s)
GTPase activator activity protein binding phosphatidylethanolamine binding phosphatidylcholine binding microtubule binding syndecan binding
Process(es)
MAPK cascade osteoblast differentiation metanephros development response to hypoxia liver development negative regulation of endothelial cell proliferation regulation of cell-matrix adhesion cell communication Ras protein signal transduction negative regulation of neuroblast proliferation brain development peripheral nervous system development heart development visual learning Schwann cell development spinal cord development forebrain astrocyte development cerebral cortex development myelination in peripheral nervous system actin cytoskeleton organization extracellular matrix organization collagen fibril organization adrenal gland development negative regulation of cell migration wound healing positive regulation of apoptotic process negative regulation of MAPK cascade pigmentation protein kinase B signaling positive regulation of neuron apoptotic process regulation of blood vessel endothelial cell migration positive regulation of GTPase activity regulation of bone resorption regulation of glial cell differentiation regulation of angiogenesis negative regulation of fibroblast proliferation sympathetic nervous system development camera-type eye morphogenesis negative regulation of oligodendrocyte differentiation smooth muscle tissue development artery morphogenesis forebrain morphogenesis regulation of developmental process cognition regulation of intracellular signal transduction positive regulation of endothelial cell proliferation negative regulation of cell-matrix adhesion negative regulation of protein kinase activity skeletal muscle tissue development negative regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors regulation of gene expression positive regulation of neuron projection development Schwann cell differentiation negative regulation of angiogenesis amygdala development neural tube development regulation of synaptic transmission, GABAergic cellular response to heat negative regulation of Rac protein signal transduction regulation of cell proliferation negative regulation of protein import into nucleus negative regulation of MAP kinase activity regulation of MAPK cascade regulation of neuron differentiation negative regulation of osteoclast differentiation positive regulation of adenylate cyclase activity negative regulation of Ras protein signal transduction negative regulation of neurotransmitter secretion regulation of long-term neuronal synaptic plasticity negative regulation of astrocyte differentiation hair follicle maturation regulation of synapse organization long-term synaptic potentiation gamma-aminobutyric acid secretion, neurotransmission glutamate secretion, neurotransmission regulation of ERK1 and ERK2 cascade cellular response to dexamethasone stimulus observational learning postsynaptic signal transduction regulation of modification of postsynaptic structure regulation of postsynapse organization regulation of long-term synaptic potentiation cellular response to nerve growth factor stimulus positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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