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Phospho-Ephrin B1/B2/B3 (Tyr324) Polyclonal Antibody

View all (3) Ephrin B1/B2/B3 antibodies

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Phospho-Ephrin B1/B2/B3 (Tyr324) Polyclonal Antibody

Product Details

PA5-103267

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human EFNB1(Accession P98172), corresponding to amino acid residues around phosphorylated Tyr324.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2815966

Product Specific Information

Antibody detects endogenous levels of Ephrin B1/B2/B3 only when phosphorylated at Tyr324.

Target Information

Eph receptors and ephrins exhibit complementary expression in many tissues during embryogenesis indicating that bidirectional activation of Eph receptors and ephrin-B proteins may occur at expression domain interfaces. Ephrin-B1 transduces outside-in signals through C-terminal protein interactions that effect integrin-mediated cell attachment and migration. The distribution of ephrin-B1 in the developing retina suggests that it influences retinal axon mapping along the dorsal-ventral axis and may be involved in intratectal development The transmembrane ligand ephrin-B2 and its receptor tyrosine kinase EphB4 are specifically expressed on arterial and venous endothelial cells, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cek ligand; CEK5 receptor ligand; Efnb2; ELK ligand; ELK-L; EPH-related receptor transmembrane ligand ELK-L3; EPH-related receptor tyrosine kinase ligand 2; EPH-related receptor tyrosine kinase ligand 5; eph-related receptor tyrosine kinase ligand 8; ephrin ligand B3; HTK ligand; LERK-2; ligand of eph-related kinase 5; ligand of EphB class receptor tyrosine kinases; ligand of the eph-related receptor tyrosine kinases hek and elk; membrane protein; stimulated by retinoic acid gene 1 protein; unnamed protein product

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Gene Aliases: Cek5-L; CFND; CFNS; EFB1; EFL-3; EFL-6; EFL3; EFL6; ELF-2; ELF-3; Elk-L; ELK-L3; ephrin-B2; Epl2; Epl5; Epl8; EPLG2; EPLG5; EPLG8; Htk-L; HTKL; LERK-2; LERK-5; LERK-8; LERK2; LERK5; LERK8; NLERK-1; NLERK-2; Stra1

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UniProt ID: (Human) P98172, (Human) P52799, (Human) Q15768, (Mouse) P52795, (Mouse) P52800, (Mouse) O35393

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Entrez Gene ID: (Human) 1947, (Human) 1948, (Human) 1949, (Rat) 25186, (Mouse) 13641, (Rat) 306636, (Mouse) 13642, (Mouse) 13643, (Rat) 360546

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Function(s)
protein binding ephrin receptor binding receptor binding receptor agonist activity transmembrane-ephrin receptor activity transmembrane receptor protein tyrosine kinase activator activity
Process(es)
cell-cell signaling nervous system development axon guidance adult walking behavior axon choice point recognition T cell costimulation ephrin receptor signaling pathway negative regulation of axonogenesis positive regulation of synaptic transmission trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission positive regulation of presynapse assembly neural crest cell migration embryonic pattern specification positive regulation of T cell proliferation presynapse assembly angiogenesis lymph vessel development cell migration involved in sprouting angiogenesis cell adhesion positive regulation of cell proliferation organ morphogenesis negative regulation of keratinocyte proliferation negative regulation of neuron projection development adherens junction organization blood vessel morphogenesis anatomical structure formation involved in morphogenesis venous blood vessel morphogenesis regulation of chemotaxis cellular response to lipopolysaccharide nephric duct morphogenesis regulation of postsynaptic membrane neurotransmitter receptor levels regulation of postsynaptic neurotransmitter receptor internalization positive regulation of aorta morphogenesis positive regulation of leukocyte adhesion to arterial endothelial cell positive regulation of cardiac muscle cell differentiation regulation of autophagosome assembly anatomical structure morphogenesis
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