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Invitrogen
ITGB1BP2 Polyclonal Antibody
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FIGURE: 1 / 4
ITGB1BP2 Antibody (PA5-103446) in ICC/IF
Immunocytochemistry analysis of ITGB1BP2 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with ITGB1BP2 polyclonal antibody (Product # PA5-103446) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-103446
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ITGB1BP2(Accession Q9UKP3), corresponding to amino acid residues M1-S41.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ITBP2.
Target Information
Integrin beta-1 binding protein 2 (ITGB1BP2), commonly referred to as Melusin, is a gene located on human chromosome 8p21.3. ITGB1BP2 is known for its role in cardiac muscle function, encoding a protein that interacts with integrin β1, which is essential for integrin signaling pathways. This gene is implicated in hypertrophic cardiomyopathy and dilated cardiomyopathy, conditions that affect heart muscle structure and function. ITGB1BP2 gene variations have been observed in families with hypertension or primary hypertrophic cardiomyopathy, although clear genotype/phenotype correlations were not conclusively established. Notably, a specific missense mutation in ITGB1BP2, involving alanine-to-glycine substitution at position 313, has been identified in patients with dilated cardiomyopathy. Melusin, the protein encoded by ITGB1BP2, plays a crucial role in mechanotransduction processes, influencing cellular responses to mechanical stress, which is particularly important in cardiac tissue adaptation and repair mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: integrin beta 1 binding protein (melusin) 2; Integrin beta-1-binding protein 2; Melusin; MGC119214
Gene Aliases: CHORDC3; ITGB1BP; ITGB1BP2; MELUSIN; MSTP015
UniProt ID: (Mouse) Q9R000
Entrez Gene ID: (Human) 26548, (Mouse) 26549
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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