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Invitrogen
Synaptotagmin 4 Polyclonal Antibody
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FIGURE: 1 / 3
Synaptotagmin 4 Antibody (PA5-104174) in ICC/IF
Immunofluorescent analysis of Synaptotagmin 4 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Synaptotagmin 4 polyclonal antibody (Product # PA5-104174) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Ale... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-104174
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SYT4(Accession Q9H2B2), corresponding to amino acid residues G74-K124.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SYT4.
Target Information
May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Synaptotagmin IV; Synaptotagmin-4; Synaptotagmin4; SytIV; unnamed protein product
Gene Aliases: HsT1192; KIAA1342; SYT4
Entrez Gene ID: (Human) 6860
vesicle fusion
memory
positive regulation of glutamate secretion
regulation of dopamine secretion
vesicle-mediated transport
regulation of calcium ion-dependent exocytosis
regulation of endocytosis
regulation of vesicle fusion
negative regulation of catecholamine secretion
negative regulation of calcium ion-dependent exocytosis
positive regulation of calcium ion-dependent exocytosis
negative regulation of short-term neuronal synaptic plasticity
negative regulation of protein secretion
calcium-dependent activation of synaptic vesicle fusion
dense core granule cytoskeletal transport
regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission
regulation of postsynaptic dense core vesicle exocytosis
negative regulation of secretion by cell
positive regulation of dendrite extension
positive regulation of dense core granule exocytosis
negative regulation of retrograde trans-synaptic signaling by neuropeptide
negative regulation of synaptic vesicle exocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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