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Invitrogen

14-3-3 beta/zeta Polyclonal Antibody

View all (5) 14-3-3 beta/zeta antibodies

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14-3-3 beta/zeta Polyclonal Antibody

Product Details

PA5-104448

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human YWHAZ(Accession P63104), corresponding to amino acid residues K158-E208.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2853749

Product Specific Information

Antibody detects endogenous levels of total 14-3-3 zeta/delta.

Target Information

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 14-3-3 alpha; 14-3-3 delta; 14-3-3 protein beta; 14-3-3 protein beta-subtype; 14-3-3 protein beta/alpha; 14-3-3 protein zeta; 14-3-3 protein zeta/delta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 zeta; 14-3-3d; 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide; epididymis luminal protein 4; epididymis secretory protein Li 1; epididymis secretory protein Li 3; epididymis secretory protein Li 93; HS1; KCIP-1; Mitochondrial import stimulation factor S1 subunit; phospholipase A2; Prepronerve growth factor RNH-1; Protein 1054; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; SEZ-2; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; unnamed protein product; YWHAE

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Gene Aliases: 1110013I11Rik; 1300003C17Rik; 14-3-3-zeta; 14-3-3z; 14-3-3zeta; AI596267; AL022924; AU020854; GW128; HEL-S-1; HEL-S-3; HEL-S-93; HEL4; HS1; KCIP-1; Msfs1; POPCHAS; YWHAA; YWHAB; YWHAD; YWHAZ

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UniProt ID: (Mouse) Q9CQV8, (Rat) P35213, (Mouse) P63101, (Rat) P63102

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Entrez Gene ID: (Human) 7529, (Human) 7534, (Mouse) 54401, (Rat) 56011, (Mouse) 22631, (Rat) 25578

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Function(s)
protein kinase inhibitor activity protein phosphatase inhibitor activity protein binding enzyme binding protein domain specific binding identical protein binding histone deacetylase binding macromolecular complex binding cadherin binding phosphoserine binding phosphoprotein binding protein sequestering activity RNA binding protein kinase binding protein phosphatase binding ubiquitin protein ligase binding ion channel binding DNA-binding transcription factor binding transcription corepressor activity protein C-terminus binding protein complex binding transcription factor binding poly(A) RNA binding scaffold/adaptor protein
Process(es)
signal transduction protein localization negative regulation of protein import into nucleus negative regulation of G-protein coupled receptor protein signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter angiogenesis respiratory system process protein phosphorylation synaptic target recognition lung development regulation of protein stability tube formation cellular response to glucose starvation negative regulation of apoptotic process negative regulation of innate immune response establishment of Golgi localization regulation of ERK1 and ERK2 cascade regulation of synapse maturation Golgi reassembly negative regulation of protein localization to nucleus negative regulation of TORC1 signaling protein targeting negative regulation of protein dephosphorylation positive regulation of catalytic activity cytoplasmic sequestering of protein protein heterooligomerization histamine secretion by mast cell protein targeting to mitochondrion regulation of cell death response to drug
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