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Invitrogen
Phospho-Afadin (Ser1799) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-104569
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human AFDN(Accession P55196), corresponding to amino acid residues around phosphorylated Ser1799.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of Afadin only when phosphorylated at Ser1799.
Target Information
AFDN belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALL-1 fusion partner from chromosome 6; ALL1-fused gene from chromosome 6 protein; FLJ34371; fusion gene; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4; protein AF-6; RP3-431P23.3; RP3-470B24.4
Gene Aliases: AF6; l-afadin; MLL-AF6; MLLT4
UniProt ID: (Human) P55196
Entrez Gene ID: (Human) 4301
cell adhesion
signal transduction
cell-cell signaling
positive regulation of gene expression
positive regulation of cell-cell adhesion
cell differentiation
negative regulation of cell migration
cell junction organization
adherens junction maintenance
cell-cell adhesion mediated by cadherin
pore complex assembly
establishment of protein localization to plasma membrane
bicellular tight junction assembly
establishment of endothelial intestinal barrier
positive regulation of cell-cell adhesion mediated by cadherin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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