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          • Primary Antibodies ›
          • Caveolin 1 Antibodies

          Invitrogen

          Phospho-Caveolin 1 (Tyr14) Polyclonal Antibody

          View all (36) Caveolin 1 antibodies

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          Cite Phospho-Caveolin 1 (Tyr14) Polyclonal Antibody

          Additional Information:

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          • Antibody Testing Data (1)
          Phospho-Caveolin 1 (Tyr14) Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          Phospho-Caveolin 1 (Tyr14) Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          Phospho-Caveolin 1 (Tyr14) Antibody (PA5-104957) in WB

          Western blot analysis of Phospho-Caveolin 1 (Tyr14) in mouse liver/rat kidney (absence (-) or presence (+) of non-phospho and phospho peptide). Samples were incubated with Phospho-Caveolin 1 (Tyr14) polyclonal antibody (Product # PA5-104957). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Phospho-Caveolin 1 (Tyr14) Antibody in Western Blot (WB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          Phospho-Caveolin 1 (Tyr14) Polyclonal Antibody

          Product Details

          PA5-104957

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunocytochemistry (ICC/IF)

          1:100-1:500
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthesized peptide derived from human CAV1(Accession Q03135), corresponding to amino acid residues around phosphorylated Tyr14.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          sequential chromatography

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2816430

          Product Specific Information

          Antibody detects endogenous levels of Caveolin 1 only when phosphorylated at Tyrosine 14.

          Target Information

          Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Bioinformatics

          Protein Aliases: caveolae; caveolin 1, caveolae protein; caveolin 1, caveolae protein, 22kDa; caveolin caveolae protein 22 kDa; caveolin, caveolae protein 1; caveolin, caveolae protein, 22 kDa; caveolin-like; cell growth-inhibiting protein 32; GIG32; HGNC:1527; OTTHUMP00000196475; unnamed protein product

          View more View less

          Gene Aliases: BSCL3; Cav; Cav-1; CGL3; LCCNS; MSTP085; PPH3; VIP21

          View more View less

          UniProt ID: (Human) Q03135, (Mouse) P49817

          View more View less

          Entrez Gene ID: (Human) 857, (Rat) 25404, (Mouse) 12389

          View more View less

          Function(s)
          receptor binding patched binding protein binding oxysterol binding cholesterol binding peptidase activator activity enzyme binding protein kinase binding protein tyrosine kinase inhibitor activity protein binding, bridging small GTPase binding nitric-oxide synthase inhibitor activity identical protein binding ion channel binding macromolecular complex binding protein heterodimerization activity nitric-oxide synthase binding ATPase binding binding, bridging inward rectifier potassium channel inhibitor activity protein sequestering activity SNARE binding kinase binding receptor serine/threonine kinase binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter angiogenesis vasculogenesis response to hypoxia negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation negative regulation of cytokine-mediated signaling pathway regulation of the force of heart contraction response to ischemia regulation of the force of heart contraction by chemical signal triglyceride metabolic process calcium ion transport cellular calcium ion homeostasis regulation of smooth muscle contraction skeletal muscle tissue development response to nutrient lactation protein localization negative regulation of cell proliferation cellular response to starvation response to xenobiotic stimulus response to mechanical stimulus response to bacterium positive regulation of signal transduction negative regulation of signal transduction response to gamma radiation positive regulation of calcium ion transport into cytosol posttranscriptional regulation of gene expression positive regulation of gene expression negative regulation of muscle cell apoptotic process positive regulation of cholesterol efflux negative regulation of smooth muscle cell migration protein transport vesicle organization receptor-mediated endocytosis of virus by host cell regulation of fatty acid metabolic process lipid storage cell differentiation regulation of blood coagulation positive regulation of cell migration negative regulation of BMP signaling pathway negative regulation of epithelial cell differentiation mammary gland development organ regeneration positive regulation of microtubule polymerization T cell costimulation negative regulation of protein ubiquitination positive regulation of protein ubiquitination receptor internalization maintenance of protein location in cell response to progesterone cholesterol efflux nitric oxide homeostasis insulin receptor internalization angiotensin-activated signaling pathway vasoconstriction negative regulation of tyrosine phosphorylation of STAT protein cholesterol homeostasis positive regulation of catalytic activity positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity negative regulation of MAPK cascade response to estrogen protein localization to plasma membrane raft negative regulation of nitric oxide biosynthetic process negative regulation of neuron differentiation positive regulation of endocytosis positive regulation of vasoconstriction negative regulation of JAK-STAT cascade microtubule polymerization negative regulation of pinocytosis negative regulation of smooth muscle cell proliferation negative regulation of nitric-oxide synthase activity response to glucocorticoid regulation of cytosolic calcium ion concentration response to calcium ion membrane depolarization regulation of peptidase activity calcium ion homeostasis mammary gland involution canonical Wnt signaling pathway negative regulation of necroptotic process negative regulation of ERK1 and ERK2 cascade caveola assembly cellular response to misfolded protein cellular response to mechanical stimulus cellular response to peptide hormone stimulus cellular response to hyperoxia cellular response to hypoxia cellular response to transforming growth factor beta stimulus basement membrane organization caveolin-mediated endocytosis regulation of heart rate by cardiac conduction negative regulation of canonical Wnt signaling pathway cellular senescence apoptotic signaling pathway regulation of membrane repolarization during action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of ventricular cardiac muscle cell action potential positive regulation of cold-induced thermogenesis regulation of ruffle assembly negative regulation of potassium ion transmembrane transport regulation of cell communication by electrical coupling involved in cardiac conduction protein localization to basolateral plasma membrane positive regulation of gap junction assembly regulation of potassium ion export across plasma membrane positive regulation of ERAD pathway negative regulation of vascular smooth muscle cell proliferation negative regulation of calcium ion import across plasma membrane regulation of entry of bacterium into host cell negative regulation of anoikis positive regulation of extrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway cholesterol transport nitric oxide metabolic process endocytosis toll-like receptor 4 signaling pathway regulation of toll-like receptor 4 signaling pathway
          It has to be done as per old AB suggested Products section.

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