Hamburger Menu Button
Thermo Fisher Scientific Logo
Sign in
Don't have an account ? Create Account
  • Products
    • PCR Equipment and Supplies
    • Chromatography Columns and Cartridges
    • Lab Centrifuges
    • Molecular Biology Reagents and Kits
    • Lab Plasticware and Supplies
    • See all product categories
  • Applications
    • Chromatography
    • Cell Culture
    • Real-Time PCR
    • Mass Spectrometry
    • Lab Plasticware and Supplies
    • Electron Microscopy
    • Protein Biology
    • PCR
    • RNAi
    • Environmental
    • See all applications and techniques
  • Services
    • Custom Services
    • Enterprise-Level Lab Informatics
    • Financial and Leasing Services
    • Instrument Services
    • OEM and Commercial Supply
    • Training Services
    • 360° CDMO and CRO Solutions
    • CDMO Services
    • CRO Services
    • Unity Lab Services
    • See all services
  • Help and Support
    • Learning Centers
    • Contact Us
    • Change Location
    • See all help and support topics
  • Popular
    • TaqMan Real-Time PCR Assays
      TaqMan Real-Time PCR Assays
    • Antibodies
      Antibodies
    • Oligos, Primers & Probes
      Oligos, Primers & Probes
    • GeneArt Gene Synthesis
      GeneArt Gene Synthesis
    • Cell Culture Plastics
      Cell Culture Plastics
  • Who We Serve
    • Antibody Therapy Solution
    • Cell and Gene Therapy Solution
    • Academic
    • Industrial and Applied Sciences
  • Contact Us
  • Quick Order
  • Order Status and Tracking
  • Documents and Certificates
Thermo Fisher Scientific Logo

Search

Search All
Search button
          • Contact Us
          • Quick Order
          • Sign in
            Sign in
            Don't have an account ? Create Account
            • Account
            • Check Order Status
            • Membership
            • AR Statement & Invoice Inquiry
            • Custom Products & Projects
          • Primary Antibodies ›
          • p53 Antibodies

          Invitrogen

          Acetyl-p53 (Lys381) Polyclonal Antibody

          View all (193) p53 antibodies

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support
          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support
          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Tech Support

          Cite Acetyl-p53 (Lys381) Polyclonal Antibody

          Additional Information:
          {{banner.description}}
          {{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
          • Antibody Testing Data (12)
          Acetyl-p53 (Lys381) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Acetyl-p53 (Lys381) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 12

          {{ $ctrl.currentElement.advancedVerification.fullName }}
          {{ $ctrl.currentElement.advancedVerification.text }}

          Acetyl-p53 (Lys381) Antibody (PA5-105110) in IHC (P)

          Immunohistochemistry analysis of Acetyl-p53 (Lys381) in human pancreatic cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Acetyl-p53 (Lys381) polyclonal antibody (Product # PA5-105110) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          View Product

          {{$ctrl.videoDesc}}

          {{$ctrl.videoLongDesc}}

          Acetyl-p53 (Lys381) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Acetyl-p53 (Lys381) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Acetyl-p53 (Lys381) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Acetyl-p53 (Lys381) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Acetyl-p53 (Lys381) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Acetyl-p53 (Lys381) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Acetyl-p53 (Lys381) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Acetyl-p53 (Lys381) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Acetyl-p53 (Lys381) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Acetyl-p53 (Lys381) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Acetyl-p53 (Lys381) Antibody in Western Blot (WB)
          Acetyl-p53 (Lys381) Antibody in Western Blot (WB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          Acetyl-p53 (Lys381) Polyclonal Antibody

          Product Details

          PA5-105110

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthesized peptide derived from human TP53(Accession P04637), corresponding to amino acid residues L369-G389.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2816583

          Product Specific Information

          Antibody detects endogenous levels of Acetyl-p53 only when acetylated at Lys381.

          Target Information

          The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent. Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors. In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory. p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

          Have you cited this product in a publication?
          Let us know so we can reference it here.
          Cite this product

          Bioinformatics

          Protein Aliases: Antigen NY-CO-13; Cellular tumor antigen p53; Cys 51 Stop; FLJ92943; HGNC11998; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p53 antigen; p53 cellular tumor antigen; Phosphoprotein p53; transcription factor; transcription factor; truncated protein; transformation related protein 53; transformation-related protein 53; tumor protein 53; tumor protein p53 (Li-Fraumeni syndrome); tumor suppressor; Tumor suppressor p53; tumor supressor p53; Tumour Protein p53; unnamed protein product

          View more View less

          Gene Aliases: bbl; BCC7; bfy; bhy; BMFS5; LFS1; p44; P53; TP53; TRP53

          View more View less

          UniProt ID: (Rat) P10361, (Mouse) P02340

          View more View less

          Entrez Gene ID: (Human) 7157, (Rat) 24842, (Mouse) 22059

          View more View less

          Function(s)
          transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding TFIID-class transcription factor binding transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protease binding p53 binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding mRNA 3'-UTR binding copper ion binding protein binding zinc ion binding enzyme binding receptor tyrosine kinase binding ubiquitin protein ligase binding histone deacetylase regulator activity annealing helicase activity identical protein binding histone deacetylase binding protein heterodimerization activity chaperone binding protein phosphatase 2A binding RNA polymerase II sequence-specific DNA binding transcription factor binding 14-3-3 protein binding MDM2/MDM4 family protein binding disordered domain specific binding general transcription initiation factor binding molecular function activator activity molecular condensate scaffold activity promoter-specific chromatin binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding transcription cofactor binding damaged DNA binding double-stranded DNA binding ATP binding protein C-terminus binding transcription factor binding protein kinase binding protein phosphatase binding histone acetyltransferase binding sequence-specific DNA binding transcription regulatory region DNA binding protein N-terminus binding protein self-association metal ion binding P53-like transcription factor
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter hematopoietic progenitor cell differentiation nucleotide-excision repair regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter autophagy apoptotic process cellular response to DNA damage stimulus response to oxidative stress ER overload response Ras protein signal transduction circadian rhythm protein localization negative regulation of cell proliferation determination of adult lifespan mRNA transcription response to xenobiotic stimulus response to UV response to ionizing radiation response to gamma radiation positive regulation of gene expression viral process negative regulation of cell growth DNA damage response, signal transduction by p53 class mediator mitotic G1 DNA damage checkpoint negative regulation of telomere maintenance via telomerase tumor necrosis factor-mediated signaling pathway cellular response to UV cellular response to glucose starvation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process entrainment of circadian clock by photoperiod positive regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of RNA polymerase II transcriptional preinitiation complex assembly positive regulation of transcription from RNA polymerase II promoter response to antibiotic negative regulation of fibroblast proliferation circadian behavior bone marrow development negative regulation of DNA metabolic process negative regulation of helicase activity protein tetramerization regulation of cell cycle hematopoietic stem cell differentiation interferon-gamma-mediated signaling pathway positive regulation of programmed necrotic cell death protein-containing complex assembly intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of thymocyte apoptotic process cellular response to hypoxia cellular response to xenobiotic stimulus cellular response to ionizing radiation cellular response to gamma radiation signal transduction by p53 class mediator intrinsic apoptotic signaling pathway by p53 class mediator cellular response to actinomycin D positive regulation of release of cytochrome c from mitochondria cellular senescence replicative senescence oxidative stress-induced premature senescence apoptotic signaling pathway intrinsic apoptotic signaling pathway oligodendrocyte apoptotic process positive regulation of execution phase of apoptosis regulation of cell cycle G2/M phase transition positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of G1 to G0 transition negative regulation of pentose-phosphate shunt positive regulation of reactive oxygen species metabolic process positive regulation of cellular senescence regulation of intrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway protein import into nucleus, translocation DNA strand renaturation in utero embryonic development somitogenesis release of cytochrome c from mitochondria T cell proliferation involved in immune response B cell lineage commitment T cell lineage commitment positive regulation of leukocyte migration response to ischemia double-strand break repair transcription from RNA polymerase II promoter protein complex assembly DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator cell cycle arrest transforming growth factor beta receptor signaling pathway multicellular organism development gastrulation negative regulation of neuroblast proliferation central nervous system development aging cell aging negative regulation of DNA replication rRNA transcription response to salt stress embryo development ending in birth or egg hatching response to inorganic substance response to metal ion response to X-ray response to UV-B response to organonitrogen compound positive regulation of cardiac muscle cell apoptotic process response to organic cyclic compound cerebellum development negative regulation of transforming growth factor beta receptor signaling pathway response to caffeine positive regulation of histone deacetylation chromatin assembly positive regulation of protein oligomerization response to retinoic acid T cell differentiation in thymus response to vitamin B3 response to cytokine regulation of tissue remodeling cellular response to heat cellular protein localization multicellular organism growth cellular response to drug positive regulation of mitochondrial membrane permeability wound healing regulation of cell proliferation response to drug response to amino acid mitochondrial DNA repair regulation of neuron apoptotic process positive regulation of neuron apoptotic process positive regulation of cell cycle negative regulation of proteolysis negative regulation of mitotic cell cycle embryonic organ development negative regulation of smooth muscle cell proliferation positive regulation of peptidyl-tyrosine phosphorylation regulation of catalytic activity chromosome organization neuron apoptotic process regulation of intracellular pH response to hyperoxia regulation of thymocyte apoptotic process necroptotic process positive regulation of cell cycle arrest cellular response to organonitrogen compound mitotic cell cycle arrest positive regulation of cell aging negative regulation of macromitophagy regulation of mitochondrial membrane permeability involved in apoptotic process regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of hydrogen peroxide-induced cell death regulation of fibroblast apoptotic process negative regulation of DNA biosynthetic process negative regulation of reactive oxygen species metabolic process regulation of cellular senescence transcription, DNA-templated cell cycle programmed cell death chromosome breakage rhythmic process positive regulation of transcription from RNA polymerase II promoter in response to hypoxia cellular response to UV-C regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter negative regulation of glucose catabolic process to lactate via pyruvate intrinsic apoptotic signaling pathway in response to hypoxia positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
          It has to be done as per old AB suggested Products section.

          Disclaimer

          Close

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          guarantee_icon

          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

          Learn more
          help_icon

          We're here to help

          Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

          Contact tech support
          Ordering Plus Icon Minus Icon
          • Order Status
          • Order Help
          • Quick Order
          • Supply Center
          • eProcurement
          Support Plus Icon Minus Icon
          • Help and Support
          • Contact Us - 400 820 8982
          • Technical Support Centers
          • Documents and Certificates
          • Report a Site Issue
          Resources Plus Icon Minus Icon
          • Learning Centers
          • Promotions
          • Events and Webinars
          • Social Media
          About Thermo Fisher Plus Icon Minus Icon
          • About Us About Us
          • Careers Careers
          • Investors Investors
          • News News
          • Social Responsibility Social Responsibility
          • Trademarks
          • Policies and Notices
          Our Portfolio Plus Icon Minus Icon
          • Thermo Scientific
          • Applied Biosystems
          • Invitrogen
          • Gibco
          • Ion Torrent
          • Unity Lab Services
          • Patheon
          • PPD
          • Terms & Conditions
          • Privacy Policy
          • Price & Freight Policy
          © 2006-2026 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
          China flag icon
          China
          本网站销售的所有产品均不得用于人类或动物之临床诊断或治疗,仅可用于工业或者科研等非医疗目的。
             电子营业执照 | 经营证照公示 | ICP备案号:沪ICP备11003924号 | 沪公网安备 31011502006935号

          Your items have has been added!


          Host server : magellan-search-green-dd86746ff-t8vjm:80/100.66.78.50:80.
          git-commit: 04e44c58f20fafe66519586ffe6db5d8a90e52ce
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.53.1-Offline